Practical application of the wound healing agent in the treatment of patients with acute paraproctitis

Introduction. Acute paraproctitis is an acute inflammation of the peri-rectal tissue, caused by the spread of the inflammatory process from the anal crypts and anal glands. One of the typical complications of treatment of all forms of acute paraproctitis is relapse of the disease. An extensive literature is devoted to this issue; it is this problem that encourages surgeons to persistently search for more rational methods of treatment. The rate of these complications ranged from 9.9% to 50%. Postoperative wound healing after opening paraproctitis is protracted, in some cases requiring repeated surgical interventions. The use of modern antiseptic solutions and dressings in the intraoperative and postoperative periods should improve the immediate results of treatment.
Aim. To study the effectiveness of the use of the wound healing agent Chitokol-KDA in the treatment of patients with acute paraproctitis.
Materials and methods. A prospective comparative randomized study was conducted in the department of coloproctology and the specialized advisory center of the Clinics of Samara State Medical University in 2024. The study included 105 patients who underwent autopsy of acute purulent paraproctitis in an inpatient setting. In the main group (n = 51), the wound healing agent Chitokol-KDA was used as an addition to treatment. In the control group (n = 54), no additional means were used during dressing.
Results and discussion. From the data obtained on the use of the wound-healing agent Chitokol-KDA, it follows that it reduces the intensity of the pain syndrome by the 3 days, and also accelerates the healing time and epithelialization of wounds (t = 2.17, p = 0.032), but does not affect the timing of the appearance of granulations (t = 0.88, p = 0.38).
Conclusion. The use of the wound-healing agent Chitokol-KDA reduces pain in the postoperative period, accelerates wound healing and does not affect the incidence of perirectal fistulas.

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