Introduction. Diabetic foot syndrome is associated with impaired reparative processes and the formation of chronic wounds, which substantiates the use of biologically active wound dressings.

Aim. Evaluate the effectiveness of application of collagen dressings in patients with diabetic foot syndrome.

Materials and methods. The study included 86 patients with diabetic foot syndrome presenting with postoperative granulating wounds. Depending on wound depth, patients were divided into two groups: superficial wounds (≤5 mm) and deep wounds (>5 mm). Within each group, patients were randomized into subgroups receiving collagen dressings of different thicknesses (2 mm and 8 mm). Treatment efficacy was assessed based on changes in wound area, wound depth, and the proportion of granulation tissue over a 20-day period.

Results. The use of collagen dressings was associated with significant improvement in all planimetric parameters of wound healing. In patients with superficial wounds, differences between treatment options were minimal, with wound area reduction of 55.6% and 53.6%, respectively. In patients with deep wounds, the use of 8 mm thick dressings resulted in a more pronounced reduction in wound depth (63.2% vs 47.3%) and a greater increase in granulation tissue (151.1% vs 102.7%) compared to 2 mm dressings (p < 0.001).

Conclusions. The differentiated use of collagen dressings depending on wound depth is an effective approach in the treatment of post-operative wounds in patients with diabetic foot syndrome. The use of thicker collagen dressings is advisable for deep wounds, whereas no significant differences in efficacy were observed in superficial defects.