The use of scaffold technologies to optimize the healing of skin wounds
https://doi.org/10.21518/akh2025-044
Abstract
Chronic wound care and wound healing management are a global public health burden that accounts for approximately 3% of total healthcare expenditure. Current therapeutic strategies used by healthcare institutions struggle to effectively handle the wound treatment, which results in long-term hospital stays. The gravity of the situation is compounded by the continuous growth of risk factors associated with chronic wound development. Therefore, it is necessary to investigate the treatment solutions that can restart wound healing by targeting specific mechanisms involved in wound repair. The article discusses topical issues of the improvement of skin wound healing by using scaffolds. The authors provide a review of current advancements in skin tissue regeneration, highlighting scaffold technologies. Today, scaffold technologies is an essential tool in different areas of regenerative medicine. The efficiency of these technologies is undoubtedly associated with their specific mechanisms aimed at providing mechanical support to reproduce the potential wound defect scaffold. Assessment of such potential requires studying the reaction of recipient tissues to matrix integration in vivo and determining the patterns of collagen fiber formation. We have analysed data from foreign and domestic sources using the search engines PubMed® and elibrary.ru over the past years. The review covers a broad spectrum of issues ranging from general principles of wound healing to a detailed description of various types of scaffolds, addressing all the key aspects of scaffold technologies. Detailed review of different types of scaffolds, their composition, properties and benefits when used to improve skin regeneration mechanisms is provided.
About the Authors
M. M. Mironov
Penza State University
Russian Federation
Russian Federation
Mikhail M. Mironov, Postgraduate Student of the Department of Surgery,
3, Lermontov St., Penza, 440000
K. I. Sergatskiy
Penza State University
Russian Federation
Russian Federation
Konstantin I. Sergatskiy, Dr. Sci. (Med.), Associate Professor, Professor of Department of Surgery,
3, Lermontov St., Penza, 440000
V. I. Nikolsky
Penza State University
Russian Federation
Russian Federation
Valery I. Nikolsky, Dr. Sci. (Med.), Professor, Professor of Department of Surgery,
3, Lermontov St., Penza, 440000
V. S. Romanova
Penza State University
Russian Federation
Russian Federation
Valeria S. Romanova, Resident of Department of Surgery,
3, Lermontov St., Penza, 440000
A. V. Shabrov
Penza State University
Russian Federation
Russian Federation
Alexandr V. Shabrov, Cand. Sci. (Med.), Associate Professor of Department of Surgery,
3, Lermontov St., Penza, 440000
A. D. Zakharov
Penza State University
Russian Federation
Russian Federation
Artem D. Zakharov, Cand. Sci. (Med.), Associate Professor of Department of Surgery,
3, Lermontov St., Penza, 440000
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For citations:
Mironov M.M., Sergatskiy K.I., Nikolsky V.I., Romanova V.S., Shabrov A.V., Zakharov A.D. The use of scaffold technologies to optimize the healing of skin wounds. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2025;22(2):234-242. (In Russ.) https://doi.org/10.21518/akh2025-044
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