Local therapy in the treatment of acute superficial vein thrombosis
https://doi.org/10.21518/akh2025-039
Abstract
According to international and Russian guidelines, superficial vein thrombosis treatment should be comprehensive and include systemic drug therapy (i.e. anticoagulant therapy), elastic compression and topical preparations. At the same time, local preparations can be self-administered, if the length of blocked portion of the vein is short and a risk of clot breaking off and travelling to the deep veins is low. The effectiveness of topical preparations has been proven to depend, among other things, on the dosage forms, and gels are characterized by more effective transdermal delivery as compared to ointments. Also, the efficacy of the active substance is affected not only by its initial concentration in the drug, but also by the extent to which the concentration is maintained after penetration into the dermis and hypodermis. The current local therapy for superficial vein thrombosis includes heparin gels and nonsteroidal anti-inflammatory drugs, as well as local cooling. The local drug therapy has an anti-inflammatory and analgesic action, and hypothermia enhances analgetic effects. Reduction in the severity of inflammatory process improves the patients' quality of life and increases their commitment to other complex treatments.
About the Authors
O. V. Dzhenina
First Phlebological Center
Russian Federation
Russian Federation
Olga V. Dzhenina, Cand. Sci. (Med.), Phlebologist, Leading Specialist,
31, Dmitry Ulyanov St., Moscow, 117447
V. Yu. Bogachev
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky;
First Phlebological Center
Russian Federation
Russian Federation
Vadim Yu. Bogachev, Dr. Sci. (Med.), Professor, Professor of the Department of Surgery, Faculty of Advanced Medical Studies, Head of the Outpatient and Aesthetic Phlebology Course, 61/2, Bldg. 1, Schepkin St., Moscow, 129110;
Scientific Supervisor, 31, Dmitry Ulyanov St., Moscow, 117447
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Review
For citations:
Dzhenina O.V., Bogachev V.Yu. Local therapy in the treatment of acute superficial vein thrombosis. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2025;22(2):149-155. (In Russ.) https://doi.org/10.21518/akh2025-039
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