Conservative treatment of hemorrhoids: focus on combination tribenoside and lidocaine
https://doi.org/10.21518/1995-1477-2019-1-2-106-111
Abstract
Hemorrhoidal disease has been known since ancient times and remains one of the most common human diseases. This review presents the results of tribenoside and lidocaine combinations used in the conservative therapy of hemorrhoids, which give grounds to recommend combination therapy with tribenoside and lidocaine in the form of rectal cream and rectal suppositories as an effective and safe method of local treatment of hemorrhoids and moderate severity in different categories of patients, allowing to achieve rapid clinical improvement.
About the Authors
D. I. Trukhan
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Trukhan Dmitry Ivanovich - Dr. of Sci. (Med.), professor of the Chair for Internal Diseases and Polyclinic Therapy.
644099, Omsk, Lenina St., 12.
E. N. Degovtsov
Omsk State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Degovtsov Eugene Nikolaevich - Dr. of Sci. (Med.), Head of the Chair for Hospital Surgery.
644099, Omsk, Lenina St., 12.
L. V. Belkina
Center for the Advanced Training of Healthcare Workers
Russian Federation
Russian Federation
Belkina Larissa Vladislavovna - Cand. of Sci. (Med.), teacher of obstetrics and gynecology.
644070, Omsk, Dekabristov Str., 35.
References
1. Vorobyev G.I., Shelygin Yu.A., Blagodarny L.A. Hemorrhoids. M.: Litera, 2010. 188 p. (In Russ).
2. Blagodarny L.A. Diagnosis and conservative treatment of hemorrhoids in the outpatient setting. Khirurgiya. 2011;2:34-7 (In Russ).
3. Blagodarny L.A., Abritsova M.V., Zhdankina S.N. Choosing conservative therapy for acute hemorrhoids. Stacionarozameshchayushchie Tekhnologii: Ambulatornaya Khirurgiya. 2018;1-2:57-63. (In Russ).
4. Tarasova L.V., Trukhan D.I. Bowel diseases. Clinical manifestations, diagnosis and treatment. SPb.: SpecLit, 2013. 144 p. (In Russ).
5. Zagryadsky E.A. Modern approaches to the treatment of hemorrhoidal disease. Khirurgiya. Prilozhenie k zhurnalu Consilium Medicum. 2012;2:36-40. (In Russ).
6. Makarov I.V., Dolgikh O.Yu. Hemorrhoids. M., 2013. 147 p. (In Russ).
7. Knorring G.Yu. The use of the combination of tribenoside and lidocaine in the local treatment of hemorrhoids: a review of clinical studies. Doctor. Ru. 2017;2(131):63-68. (In Russ).
8. Lohsiriwat V. Treatment of hemorrhoids: A coloproctologist’s view. World J Gastroenterol. 2015 Aug 21;21(31):9245-52. doi:10.3748/wjg.v21.i31.9245.
9. Mounsey A.L., Halladay J., Sadiq T.S. Hemorrhoids. Am. Fam. Physician. 2011;2:204–10.
10. Riss S., Weiser F.A., Schwameis K. et al. The prevalence of hemorrhoids in adults. Int J. Colorectal. Dis. 2012;2:215–220.
11. Shekhtman M.M., Kozinova N.V. Hemorrhoids in pregnant women. Gynecology. 2004;6(6):7-12. (In Russ).
12. Abramowitz L. Management of hemorrhoid disease in the pregnant woman. Gastroenterol Clin Biol. 2008 May, 32(5 Pt 2):S210-4. Epub 2008 May 23.
13. Elokhina TB, Tyutyunnik V.L., Balushkina A.A. Hemorrhoids: principles of therapy in obstetric practice. RMJ. Mat i Ditya. 2010;4:200-203. (In Russ).
14. Tyutyunnik V.L., Kirsanova T.V., Mikhailova O.I. Hemorrhoids in obstetric practice: etiology, pathogenesis, clinical manifestations, treatment. Rossijskiy Vestnik Akushera-Ginekologa. 2012;4:88-92. (In Russ).
15. Wall L.L. Pelvis, posture and protrusion: evolution and haemorrhoids. BJOG. 2014;121(13):1672.
16. Zielinski R., Searing K., Deibel M.J. Gastrointestinal distress in pregnancy: prevalence, assessment, and treatment of 5 common minor discomforts. Perinat Neonatal Nurs. 2015;29(1):23-31.
17. Lomova N.A., Dubrovina N.V., Dragun I.E., Tolstopyatova E.S. Hemorrhoids in pregnant women and puerperas: principles of therapy. Meditsinsky Sovet. 2016;2:22-25. (In Russ).
18. Quijano C.E., Abalos E. Conservative management of symptomatic and/or complicated haemorrhoids in pregnancy and the puerperium. Cochrane Database Syst. Rev. 2005;3:CD004077.
19. Staroselsky A., Nava-Ocampo A.A., Vohra S., Koren G. Hemorrhoids in pregnancy. Can. Fam. Physician. 2008;2(54):189–190.
20. Trukhan D.I., Filimonov S.N. Differential diagnosis of major gastroenterological syndromes and symptoms. M.: Practical medicine, 2016. 168 p. (In Russ).
21. Trukhan D.I. Blood in stool: issues of differential diagnosis. Spravochnik Poliklinicheskogo Vracha. 2016;06:38-42. (In Russ).
22. Trukhan D.I., Nikonenko V.A. Differential diagnosis of blood in stool. Exact examination is the key to successful treatment. Stacionarozameshchayushchie Tekhnologii: Ambulatornaya Khirurgiya. 2016;3-4(63–64):36-43. (In Russ).
23. Trukhan D.I., Filimonov S.N. Intestinal diseases: clinical presentation, diagnosis and treatment. Novokuznetsk: Polygraphist LLC, 2017. 223 p. (In Russ).
24. Lohsiriwat V. Hemorrhoids: from basic pathophysiology to clinical management. World J Gastroenterol. 2012;18:2009–2017.
25. Fathallah N., Barre A., Crochet É., Pommaret É., De Parades V. Management of anorectal bleeding. Rev Prat. 2017 Feb;67(2):152-159.
26. Mott T., Latimer K., Edwards C. Hemorrhoids: Diagnosis and Treatment Options. Am Fam Physician. 2018 Feb 1;97(3):172-179.
27. Clinical Practice Committee, American Gastroenterological Association. American Gastroenterological Association medical position statement: Diagnosis and treatment of hemorrhoids. Gastroenterology. 2004;126:1461–1462.
28. Misra M.C. Drug treatment of haemorrhoids. Drugs. 2005;65:1481–1491.
29. Perera N., Liolitsa D., Lype S. et al. Phlebotonics for haemorrhoids. Cochrane Database Syst Rev. 2012;8:CD004322.
30. Lorenc Z., Gökçe Ö. Tribenoside andlidocaine in thelocal treatment of hemorrhoids: an overview of clinical evidence. Eur Rev Med Pharmacol Sci. 2016 Jun;20(12):2742-2751.
31. Jaques R. The pharmacological activity of tribenoside. Pharmacology. 1977;15(5):445-460.
32. Rüegg M., Jaques R. Tribenoside as an inhibitor of chemically induced histamine release. Experientia. 1974 Apr 15;30(4):399-401.
33. Majer H. Stabilization of rat erythrocytes against the haemolytic effect of glass particles by tribenoside. Agents Actions. 1975 May;5(2):161-163.
34. Kakande I. Glyvenol therapy in varicose veins an evaluation of its effectiveness. East Afr Med J. 1981 Jul;58(7):532-538.
35. Spinella G., Majorana M. Tribenoside in the treatment of varicose disease of thelowerlimbs: controlled clinical study. Clin Ter. 1982 Jun 30;101(6):587-601.
36. Wilhelmi G. Regeneration-promoting properties of tribenoside in Amblystoma mexicanum. Pharmacology. 1976;14(5):397-404.
37. Kikkawa Y., Takaki S., Matsuda Y. et al. The influence of Tribenoside on expression and deposition of epidermallaminins in HaCaT cells. Biol. Pharm. Bull. 2010;2(33):307–310.
38. Barkin R.L. The pharmacology of topical analgesics. Postgrad. Med. 2013;4(Suppl. 1):7–18.
39. Altomare D.F., Giannini I. Pharmacological treatment of hemorrhoids: a narrative review. Expert. Opin. Pharmacother. 2013;17(14):2343–2349.
40. Rizzi B., Giacomini F., Bandini V. Terapialocale della sindrome emorroidaria con etil-3,5,6-tri-o-benzil-d-glicofuranoside: risultati clinici. Gazz Int Med Chirur. 1972;77:1598-1606.
41. Moggian G. Sperimentazione clinica controllata di un derivato glicofuranosidico anti-emorroidario, per usolocale. Minerva Med. 1973;64:215-218.
42. Marques J.R., DaSilva J.H., Galizia I. et al Ensaio controlado com Procto-Glyvenol no tratamento das hemorroides. Rev Bras De Cirurgia. 1972;62:7-8.
43. Angriman J., Neumayer F. Tratamiento delas hemorroides con glucofuranosido crema. Orientación Médica. 1972;31:353-354.
44. Berson I, Geiser JD. Utilisation d’un nouveau produit:le procto-glyvenol en pratique proctologique. Revue Suisse de Médecine (Praxis) 1975;63:19-22.
45. Berson I., Geiser J.D. A new medicine in proctology: the procto-glyvenol (author’s transl). Schweiz Rundsch Med Prax. 1975 Jan 7;64(1):19-22.
46. Berson I. Local treatment of acute hemorrhoidal crises (author’s transl). Schweiz Rundsch Med Prax. 1975 Mar 11;64(10):299-301.
47. Holzer A. Betrachtungen über ano-rektaleleidenszustände und ihre behandlung. Der Praktische Arzt. 1976; 30:662-672.
48. Kubicsek T., Kazy Z., Czeizel A.E. Teratogenic potential of tribenoside, a drug for the treatment of haemorrhoids and varicose veins-a population-based case--control study. Reprod Toxicol. 2011 May;31(4):464-469. doi: 10.1016/j.reprotox.2010.12.001. Epub 2010 Dec 21.
49. Sokolova, T.A. Procto glevenol in the treatment of acute uterine diseases in women. Uspekhi Sovremennogo Estestvoznaniya. 2005;9:103-104. (In Russ).
50. Pregnancy and Lactation Labeling (Drugs) Final Rule. URL: https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentRe-sources/Labeling/ucm093307.htm.
Review
For citations:
Trukhan D.I., Degovtsov E.N., Belkina L.V. Conservative treatment of hemorrhoids: focus on combination tribenoside and lidocaine. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2019;(1-2):106-111. (In Russ.) https://doi.org/10.21518/1995-1477-2019-1-2-106-111
Views:
1525
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International.
Email this article 