Possibilities of treatment of symptoms of chronic diseases of lower limbs veins
https://doi.org/10.21518/1995-1477-2019-1-2-34-37
Abstract
The review presents literature on the epidemiology of chronic venous diseases (CVD) and chronic venous insufficiency (CVI). The main approaches to the choice of conservative therapy for CVD and CVI are presented. The rationality of symptomatic treatment of this category of patients is justified. Data on clinical effects and mechanisms of their realization in the preparation of calcium dobesilate are given. The results of preclinical and clinical studies to assess the efficacy and safety of calcium dobesilate in relation to the symptomatic treatment of CVD and CVI are presented. On the basis of the analysis of literary sources the conclusion on expediency of wide application of calcium dobesilate in phlebological practice is presented.
About the Author
M. N. Kudykin
Association of Angiologists, Phlebologists and Vascular Surgeons of Nizhny Novgorod Region
Russian Federation
Russian Federation
Kudykin Maxim Nikolayevich – Dr. of Sci. (Med), Executive Director of the public organization «Association of Angiologists, Phlebologists and Vascular Surgeons of Nizhny Novgorod Region»; Vice-President of «Association of Phlebologists of Russia».
603141, Nizhny Novgorod Region, Nizhny Novgorod, Geologov St., 1, bldg. 29.
References
1. Rabe E., Pannier F. Epidemiology of chronic venous disorders. In: Gloviczki P ed. Handbook of Venous Disorders. London: Hodder Arnold. 2009:105–110.
2. Criqui M.H., Jamosmos M., Fronek A., et al. Chronic venous disease in an ethnically diverse population. The San Diego Population Study. Am J Epidemiol. 2003;158:448–56.
3. Maurins U., Hoffmann B., Lösch C., Jöckel K.H., Rabe E., Pannier F. Distribution and prevalence of reflux in the superficial and deep venous system in the general population – results from the Bonn Vein Study. J Vasc Surg. 2008;48:680–7.
4. Langer R.D., Ho E., Denenberg J.O., Fronek A., Allison M., Criqui M.H. Relationships between symptoms and venous disease: the San Diego population study. Arch Internal Med. 2005;165:1420–4.
5. Seliverstov E.I., Avakyants I.P., Nikishkov A.S., Zolotukhin I.A. Epidemiology of chronic vein diseases. Phlebology [Flebologija]. 2016;10(1):35-43. (In Russ.)
6. Zolotukhin I.A. Chronic Venous Diseases in Women: Results of the Russian DEVA screening study. Consilium Medicum. 2008;8:128-131. (In Russ.)
7. Bollinger A., Herrig I., Fischer M., Hoffmann U., Franzeck U.K. Intravital capillaroscopy in patients with chronic venous insufficiency andlymphoedema: relevance to Daflon 500 mg. Int J Microcirc Clin Exp. 1995;15:41–4.
8. Labs K.-H., Degischer S., Gamba G., Jaeger K.A. Effectiveness and safety of calcium dobesilate in treating chronic venous insufficiency: randomized, double-blind, placebo-controlled trial. Phlebology. 2004;19:123–30.
9. Martínez-Zapata M.J., Moreno R.M., Gich I., Urrútia G., Bonfill X. Chronic Venous Insufficiency Study Group. A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease. Eur J Vasc Endovasc Surg. 2008;35:358–65.
10. Flota-Cervera F., Flota-Ruiz C., Trevino C., Berber A. Randomized, double blind, placebo-controlled clinical trial to evaluate the lymphagogue effect and clinical efficacy of calcium dobesilate in chronic venous disease. Angiology. 2008;59(3):352-356.
11. Alda O., Valero M.S., Pereboom D., Serrano P., Azcona J.M., Garay R.P. In vitro effect of calcium dobesilate on oxidative/ inflammatory stress in human varicose veins. Phlebology. 2011;26(8):332-3337. doi:10.1258/phleb.2010.010052.
12. Rabe E., Jaeger K.A., Bulitta M., Pannier F. Calcium dobesilate in patients suffering from chronic venous insufficiency: a double-blind, placebo-controlled, clinical trial. Phlebology. 2011;26(4):162-8. doi:10.1258/phleb.2010.010051.
13. Rabe E., Ballarini S., Lehr L. A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. Phlebology. 2016;31(4): 264-274. doi:10.1177/0268355515586097.
14. Akbulut В. Calcium dobesilate and oxerutin: effectiveness of combination therapy Phlebology. 2010;25(2):66-71. doi:10.1258/phleb.2009.008085.
15. Allain H., Ramelet A.A., Polard E., Bentue-Ferrer D. Safety of calcium dobesilate in chronic venous disease, diabetic retinopathy and haemorrhoids. Drug Safety. 2004;27(9):649-660. doi:10.2165/00002018-200427090-00003.
16. Russian Clinical Recommendations for Diagnostics and Treatment of Chronic Venous Diseases. Phlebology [Flebologija]. 2018;3(3):143-240. (In Russ.)
Review
For citations:
Kudykin M.N. Possibilities of treatment of symptoms of chronic diseases of lower limbs veins. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2019;(1-2):34-37. (In Russ.) https://doi.org/10.21518/1995-1477-2019-1-2-34-37
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