Ketorolac in a multimodal pain management scheme
Abstract
Pain, as a powerful trigger of stress response to surgery, largely determines the results of surgical treatment through neurohormonal, endocrine, immune, metabolic and hemostatic mechanisms. The most commonly used NSAID is ketorolac (ketorol) which is administered parenterally. Improvements in the quality of postoperative analgesia predetermined the creation of a protocol with NSAIDs as the basic medications. For the treatment of postoperative pain, the Clinical Centre currently uses a combination of drugs with different mechanisms of action depending on the type of surgery, the nature and severity of primary and associated pathology in patients. For this purpose, NSAIDs are initially administered as they reduce activation of nocicep-tors in peripheral tissues; anesthesia with preferential inhibition of transmission of pain impulse at the segmental and suprasegmental levels is also applied.
About the Authors
B. K. Vandanov
Branch Clinical Diagnostic Center of PJSC Gazprom
Russian Federation
Russian Federation
A. N. Shikhmetov
Branch Clinical Diagnostic Center of PJSC Gazprom
Russian Federation
Russian Federation
N. N. Lebedev
Branch Clinical Diagnostic Center of PJSC Gazprom
Russian Federation
Russian Federation
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Review
For citations:
Vandanov B.K., Shikhmetov A.N., Lebedev N.N. Ketorolac in a multimodal pain management scheme. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2017;(1-2):65-69. (In Russ.)
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