Experience in the use of collagen dressings in surgical practice
https://doi.org/10.21518/akh2025-012
Abstract
Introduction. Trophic ulcers of the lower extremities represent one of the serious problems in modern medicine, especially among patients with diabetic foot syndrome (DFS). Despite significant advances in developing new treatment methods, this pathology remains difficult to cure due to prolonged wound healing periods and a high risk of amputations.
Aim. To evaluate the effectiveness, safety, and convenience of using collagen dressings for treating chronic wounds with long healing times at various stages of the wound process.
Materials and methods. The study was conducted based on the surgical department of Dr. Begma’s Medical Center. The results of treating 37 patients with trophic ulcers caused by DFS, who were treated with the collagen dressing Digestol, were analyzed. Dynamics of wound healing, changes in surrounding tissues, reduction of pain syndrome, and other indicators were assessed. The article also includes a clinical case of applying a collagen wound dressing.
Results. As a result of using the collagen dressing, there was a significant reduction in the time required for ulcer defects to heal, an improvement in the condition of surrounding tissues, and a decrease in pain and edema. The average full-healing period was 12 weeks, which is significantly shorter than that achieved through traditional treatment methods.
Discussion. The obtained results confirm the high efficacy of collagen dressings in treating trophic ulcers, particularly under conditions of long-term chronic disease progression. They demonstrated the ability to maintain optimal moisture levels, provide non-traumatic effects, and facilitate rapid tissue repair.
Conclusions. Biological collagen dressing is an effective tool for treating trophic ulcers. Using the biological dressing as part of complex therapy allows for faster wound cleansing, accelerates the healing process of ulcerative lesions of the lower limbs, improves patient quality of life, and reduces the risk of amputations.
About the Authors
A. N. Begma
Doctor Begma’s Medical Center
Russian Federation
Russian Federation
Andrey N. Begma, Cand. Sci. (Med.), Surgeon, Chief Physician,
20, Svobody St., Moscow, 125362
H. M. De
Doctor Begma’s Medical Center;
City Clinical Hospital No. 15 named after O.M. Filatov
Russian Federation
Russian Federation
De Hen Mi, Surgeon, Surgeon, 20, Svobody St., Moscow, 125362;
Surgeon, 23, Veshnyakovskaya St., Moscow, 111539
P. B. Ustaalieva
Doctor Begma’s Medical Center;
Pirogov Russian National Research Medical University;
City Clinical Hospital No. 24
Russian Federation
Russian Federation
Patimat B. Ustaalieva, Surgeon, 20, Svobody St., Moscow, 125362;
Assistant of the Department of General Surgery, 1, Ostrovityanov St., Moscow, 117513;
Surgeon, 10, Pistsovaya St., Moscow, 127015
References
1. Bregovskiy VB, Demina AG, Karpova IA. The use of modern dressings for the local treatment of diabetic foot ulcers in out-patient setting. Ambulatornaya Khirurgiya. 2022;19(2):72–81. (In Russ.) https://doi.org/10.21518/1995-1477-2022-19-2-72-81.
2. Nicolaides AN. Investigation of chronic venous insufficiency: A consensus statement (France, March 5–9, 1997). Circulation. 2000;102(20):E126–E163. https://doi.org/10.1161/01.cir.102.20.e126.
3. Diabetes Аtlas. International Diabetes Federation. 3rd ed. Brussels; 2007. 381 p. Available at: https://diabetesatlas.org/atlas/third-edition/.
4. Suntsov YuI, Bolotskaya LL, Maslova OV, Kazakov IV. Epidemiology of diabetes mellitus and prognosis of its prevalence in the Russian Federation. Diabetes Mellitus. 2011;14(1):15–19. (In Russ.) https://doi.org/10.14341/2072-0351-6245.
5. Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 2017;376(24):2367–2375. https://doi.org/10.1056/NEJMra1615439.
6. Crawford F, McCowan C, Dimitrov BD, Woodburn J, Wylie GH, Booth E et al. The risk of foot ulceration in people with diabetes screened in community settings: findings from a cohort study. QJM. 2011;104(5):403–410. https://doi.org/10.1093/qjmed/hcq227.
7. Abbott CA, Carrington AL, Ashe H, Bath S, Every LC, Griffiths J et al. The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabet Med. 2002;19(5):377–384. https://doi.org/10.1046/j.1464-5491.2002.00698.x.
8. Udovichenko OV, Bublik EV. Use of Biatain dressing material in patients with diabetic foot syndrome: randomized comparative study. Diabetes Mellitus. 2009;12(1):18–21. (In Russ.) https://doi.org/10.14341/2072-0351-5414.
9. Кузин МИ, Костюченок БМ (ред.). Раны и раневая инфекция. 2-е изд., перераб. и доп. М.: Медицина; 1990. 592 с. Режим доступа: https://djvu.online/file/OL8uNIq5baEiK.
10. Lutsevich OE, Tamrazova OB, Shikunova AYu, Pleshkov AS, Ismailov GIO, Vorotilov YuV, Tolstikh PI. Pathogenesis of septic wounds. Pirogov Russian Journal of Surgery. 2011;(5):72–77. (In Russ.) Available at: https://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-pirogo va/2011/5/030023-12072011515.
11. Lobmann R, Schultz R, Lechnert H. Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications. Diabetes Care. 2005;28(2):461–471. https://doi.org/10.2337/diacare.28.2.461.
12. Bublik EV, Korshunova YuV, Krupinova YuA, Morozova OA. Pathogenetic aspects of the wound care in diabetic patients. A new silver alginate dressing Fibroclean Ag: what are benefits? Wounds and Wound Infections. The prof. B.M. Kostyuchenok Journal. 2015;2(1):20–25. (In Russ.) https://doi.org/10.17650/2408-9613-2015-2-1-20-25.
13. American Diabetes Association. Consensus Development Conference on Diabetic Foot Wound Care: 7–8 April 1999, Boston, Massachusetts. American Diabetes Association. Diabetes Care. 1999;22(8):1354–1360. https://doi.org/10.2337/diacare.22.8.1354.
14. Udovichenko OV, Galstyan GR. Algorithms of selection of dressing materials for treatment of the diabetic foot syndrome (by the examples of Paul Hartmann dressings). Diabetes Mellitus. 2006;9(1):46–52. (In Russ.) https://doi.org/10.14341/2072-0351-5381.
15. Tokmakova AYu, Strakhova GYu, Galstyan GR. Modern concept of management of patients with chronic wounds and diabetes. Diabetes Mellitus. 2005;8(1):42–48. (In Russ.) https://doi.org/10.14341/2072-0351-5441.
16. Bernard FX, Barrault C, Juchaux F, Laurensou C, Apert L. Stimulation of the proliferation of human dermal fibroblasts in vitro by a lipidocolloid dressing. J Wound Care. 2005;14(5):215–220. https://doi.org/10.12968/jowc.2005.14.5.26775.
17. Bregovskyi VB. Wound bandage basing on lipidocolloid technology application experience in outpatient treatment of foot trophic ulcer. Endocrine Surgery. 2011;5(1):29–33. (In Russ.) https://doi.org/10.14341/2306-3513-2011-1-29-33.
18. Rangaraj A, Harding K, Leaper D. Role of collagen in wound management. Wounds UK. 2011;7(2):54–63. Available at: https://wounds-uk. com/journal-articles/role-of-collagen-in-wound-management/.
19. Ostroushko AP, Andreev AA, Laptyova AYu, Glukhov AA. Collagen and Use Its in the Treatment of Wounds. 2021;14(1):85–90. (In Russ.) https://doi.org/10.18499/2070-478X-2021-14-1-85-90.
20. Fleck CA, Simman R. Modern Collagen Wound Dressings: Function and Purpose. J Am Col Certif Wound Spec. 2010;2(3):50–54. https://doi.org/10.1016/j.jcws.2010.12.003.
21. Glyantsev SP, Vishnevsky AV, Adamyan AA, Vishnevsky AV, Sakharov IYu. Crab collagenase in wound debridement. J Wound Care. 1997;6(1):13–16. https://doi.org/10.12968/jowc.1997.6.1.13.
22. Teplikov AV, Cherepanin AI. Experience in the use of wound-healing collagen dressings in the complex treatment of venous trophic ulcers. Lechaschi Vrach. 2024;27(7):23–29. (In Russ.) https://doi.org/10.51793/OS.2024.27.7.003.
Review
For citations:
Begma A.N., De H.M., Ustaalieva P.B. Experience in the use of collagen dressings in surgical practice. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2025;22(1):132-139. (In Russ.) https://doi.org/10.21518/akh2025-012
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