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The possibility of using a topical combined antibacterial agent in the prevention of infection during surgical intervention

https://doi.org/10.21518/1995-1477-2019-1-2-87-92

Abstract

The article  presents the  results  of the  clinical  study  on the  assessment of the  preventive  clinical  effectiveness of the  topical combined antibacterial drug bacitracin/neomycin in the prevention  of infection during surgical intervention.

The study included 112 patients whose average age was 42.4+7.4 years. Patients were divided into groups according to the risk of infection of the surgical area (SSI) according to the criteria of D.C. Classen et al. and into subgroups according to whether standard antiseptic therapy or topical antibacterial therapy with bacitracin/neomycin was used in the postoperative period.

The study demonstrated high preventive  efficacy of the topical drug bacitracin/neomycin in the prevention  of various clinical forms of SSI and, probably, in the prevention  of seromas of postoperative wounds.

About the Authors

M. V. Zhuchkov
Regional Clinical Dermatovenereological Dispensary
Russian Federation

Zhuchkov Mikhail Valeryevich – Candidate of Medical Sciences, Deputy Chief Doctor of the Clinical Dermatovenerological Dispensary, Chief Freelance Specialist of Dermatology and Cosmetology of the Ministry of Health of the Ryazan Region.

390046, Ryazan, Sportivnaya St., 9; tel:+7 (906) 647-89-19.



U. V. Zhuchkova
City Clinical Emergency Hospital
Russian Federation

Zhuchkova Ulyana Vladimirovna - Candidate of Medical Sciences, Surgeon.

390013, Ryazan, Dzerzhinskogo St., 11.



S. V. Tarasenko
Ryazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of the Russian Federation
Russian Federation

Tarasenko Sergey Vasilyevich – Dr. of Sci. (Med), Professor, Head of the Departmentof Hospital Surgery of the Ryazan State Medical University named after Academician I.P. Pavlov of the Ministry of Health of the Russian Federation, Chief Doctor of the State Budgetary Institution of the Ryazan region City Clinical Emergency Hospital.

390013, Ryazan, Vysokovoltnaya St., 9; 390013, Ryazan, Dzerzhinskogo St., 11.



References

1. Janjua M.B., Toll B., Ghandi S., Sebert M.E., Swift D.M., Pahys J.M., Samdani A.F., Hwang S.W. Risk Factors for Wound Infections after Deformity Correction Surgery in Neuromuscular Scoliosis. Pediatr Neurosurg. 2019 Feb 15:1-8.

2. Classen D.C., Evans R.S., Pestotnik S.L., Horn S.D., Menlove R.L., Burke J.P. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992 Jan 30;326(5):281-286.

3. Trocha K., Kip P., MacArthur M.R., Mitchell S.J., Longchamp A., Treviño-Villarreal J.H., Tao M., Bredella M.A., De Amorim Bernstein K., Mitchell J.R., Ozaki C.K. Preoperative Protein or Methionine Restriction Preserves Wound Healing and Reduces Hyperglycemia. J Surg Res. 2019 Mar;235:216-222.

4. Mayhall C. G. Surgical infections including burns. In: Ed. R. P. Wenzell. Prevention and control of nosocomial infections / C. G. Mayhall. Baltimore, MD: Williams & Wilkins. 1993:614–644.

5. Horan T.C., Gaynes R.P., Martone W.J., Jarvis W.R., Emori T.G. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol. 1992 Oct;13(10):606-608.

6. Levin E.C., Chow C., Makhzoumi Z., Jin C., Shiboski S.C., Arron S.T. Association of Postoperative Antibiotics With Surgical Site Infection in Mohs Micrographic Surgery. Dermatol Surg. 2019 Jan;45(1):52-57.

7. Sheth J., Rath S., Tripathy D. Oral versus single intravenous bolus dose antibiotic prophylaxis against postoperative surgical site infection in external dacryocystorhinostomy for primary acquired nasolacrimal duct obstruction - A randomized study. Indian J Ophthalmol. 2019 Mar;67(3):382-385.

8. Weinstein L. The newer antibiotics: a brief review of the biological and clinical properties of bacitracin, polymyxin, aureomycin, chloromycetin and neomycin. Ohio State Med J. 1950 Jun;46(6):246-253.

9. Rattner H., Rodin H.H. Treatment of pyodermas with penicillin 92; comparison with neomycin and bacitracin. AMA Arch Derm Syphilol. 1952 Jun;65(6):656-662.

10. Gade M., Korner B., Sylvest B. Topical neomycin-bacitracin therapy in pyogenic skin infections. Acta Derm Venereol. 1953;33(6):476-487.

11. Lund E. Sensitivity of bacteria to bacitracin and neomycin. Acta Pathol Microbiol Scand. 1953;33(2):163-170.

12. Canonero R., Ferraris A., Martelli A. Toxic effect on rat hepatocytes induced by the oral administration of a bacitracin-neomycin combination. Boll Soc Ital Biol Sper. 1986 Jul 30;62(7):865-870.

13. Greenhouse J.M., Ryle W.C. Combined bacitracin-neomycin ointment in treatment of pyogenic infections of the skin. AMA Arch Derm Syphilol. 1954 Mar;69(3):366-367.

14. Panaccio V. Topical treatment of various skin infections with an antibiotic polymyxin B-bacitracin-neomycin ointment. Can Med Assoc J. 1956 Oct 1;75(7):592-593.

15. Garnes A.L., Corbin E.E., Prigot A. Local therapy of burns with a neomycin-bacitracin spray powder. Antibiotic Med Clin Ther (New York). 1960 May;7:291-294.

16. Mehta T.K., Mehta V.R. The Management of Pyodermas and Eczematous Dermatoses with Varied Combinations of Neomycin, Bacitracin, Sulphacetamide and Hydrocortisone in an Ointment Base. Indian J Dermatol Venereol. 1965 Jan-Feb;31(1):14-22.

17. Tsolakas T.C., Davies J.P., Oram S. Staphylococci resistant to neomycin bacitracin. Lancet. 1965 Aug 28;2(7409):421-422.

18. Delmotte A., Beumer J. Sensitivity of Bacillus pyocyaneus (Pseudomonas aeruginosa) to antiseptics and antibiotics. VIII. Action of the combination zinc bacitracin, neomycin sulfate and polymyxin B sulfate on 155 strains of Pseudomonas aeruginosa (1st part). Therapie. 1975 Mar-Apr;30(2):289-298.

19. Benjamin J.B., Volz R.G. Efficacy of a topical antibiotic irrigant in decreasing or eliminating bacterial contamination in surgical wounds. Clin Orthop Relat Res. 1984 Apr;184:114-117.

20. Khoruk S.M., Krechikov V.A. Results of application of the combined drug bacitracyn-neomycin in the postoperative period during cosmetic operations to recover soft tissue defects of the maxillofacial area. Surgery. Magazine named after N.I. Pirogov [Hirurgiya. Zhurnal im. N.I. Pirogova. 2008;12:47-50.] (In Russ.)

21. Sood A., Taylor J.S. Bacitracin: allergen of the year. Am J Contact Dermat. 2003 Mar;14(1):3-4.

22. Pirila V., Kajanne H. Neomycin and bacitracin sensitization. Duodecim. 1961;77:764-770.

23. Ma Y., Zhang N., Wu S., Huang H., Cao Y. Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China. Front Med. 2016 Dec;10(4):517-521.

24. Abu Samra M., El Bendary H., Hayes S.M., Elhadidy M.B. Role of topical antibiotic prophylaxis in prevention of bacterial translocation into upper trachea in nasally intubated patients undergoing tonsillectomies. Int J Pediatr Otorhinolaryngol. 2013 Feb;77(2):270-274.


Review

For citations:


Zhuchkov M.V., Zhuchkova U.V., Tarasenko S.V. The possibility of using a topical combined antibacterial agent in the prevention of infection during surgical intervention. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2019;(1-2):87-92. (In Russ.) https://doi.org/10.21518/1995-1477-2019-1-2-87-92

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