Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins
https://doi.org/10.21518/1995-1477-2019-1-2-27-33
Abstract
This review examines the development of endothelial dysfunction in chronic venous diseases (СVD), the multifactority of this process. The important role of the nitric oxide system as a universal modulator of various biochemical reactions and realization of many important physiological functions is shown. The need for early pharmacotherapy of phleboprotectors with endothelioprotective activity is discussed in order to slow the progression of CVD. Effects of flavonoids as perspective endothelioprotectors on various links in the pathogenesis of endothelial dysfunction are considered. On the example of the micronized purified flavonoid fraction (MPFF), the effect of flavonoid compounds on endothelial dysfunction in CVD is demonstrated, and the mechanisms of action have been examined in detail. In addition, the pharmacological effects of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed. Features of the micronized form that affect bioavailability and, ultimately, determine the pharmacological effectiveness of the drug are considered.
Keywords
About the Authors
A. V. Voronkov
Pyatigorsk Medical and Pharmaceutical Institute, a branch of the state budgetary educational institution of higher professional education «Volgograd State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Voronkov Andrey Vladislavovich – Dr. of Sci. (Med), Associate Professor, Head of the Department of Pharmacology with the course of clinical pharmacology.
357532, Stavropol Territory, Pyatigorsk, Kalinina Avenue, 11.
O. Yu. Gamzeleva
Pyatigorsk Medical and Pharmaceutical Institute, a branch of the state budgetary educational institution of higher professional education «Volgograd State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Gamzeleva Olesya Yurievna – lecturer at the Department of Pharmacology with the course of clinical pharmacology.
357532, Stavropol Territory, Pyatigorsk, Kalinina Avenue, 11.
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Review
For citations:
Voronkov A.V., Gamzeleva O.Yu. Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins. Ambulatornaya khirurgiya = Ambulatory Surgery (Russia). 2019;(1-2):27-33. (In Russ.) https://doi.org/10.21518/1995-1477-2019-1-2-27-33
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