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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">asurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Амбулаторная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8741</issn><issn pub-type="epub">2782-2591</issn><publisher><publisher-name>ООО «ГРУППА РЕМЕДИУМ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">asurgery-93</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АМБУЛАТОРНАЯ АНЕСТЕЗИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OUTPATIENT ANESTHESIA</subject></subj-group></article-categories><title-group><article-title>Нимесулид в лечении и профилактике болевого синдрома различного генеза</article-title><trans-title-group xml:lang="en"><trans-title>Nimesulid: treatment and prevention of pain syndrome of various origin</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шень</surname><given-names>Н. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Shen</surname><given-names>N. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логвиненко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Logvinenko</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухачева</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhacheva</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Областная клиническая больница №1; Тюменский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital No1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Областная клиническая больница №2; Тюменский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Clinical Hospital No 2; Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2017</year></pub-date><volume>0</volume><issue>3-4</issue><fpage>75</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шень Н.П., Логвиненко В.В., Мухачева С.Ю., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Шень Н.П., Логвиненко В.В., Мухачева С.Ю.</copyright-holder><copyright-holder xml:lang="en">Shen N.P., Logvinenko V.V., Mukhacheva S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.a-surgeon.ru/jour/article/view/93">https://www.a-surgeon.ru/jour/article/view/93</self-uri><abstract><p>Болевой синдром в практике многих специалистов, в том числе и амбулаторного звена, является важной и актуальной проблемой. В лечении болевого синдрома эффективными и безопасными препаратами являются селективные ингибиторы циклооксигеназы (ЦОГ), представителем которых является нимесулид. Являясь ингибитором ЦОГ-2, он, хотя и не превосходит традиционные неселективные противовоспалительные препараты по своей активности, обеспечивает большую безопасность применения у пациентов как с острой хирургической, так и с хронической соматической патологией. Настоящий обзор позволяет сделать заключение о нимесулиде как препарате выбора на догоспитальном и госпитальном этапе у пациентов с острым и хроническим болевым синдромом, особенно у больных с коморбидной патологией.</p></abstract><trans-abstract xml:lang="en"><p>Pain syndrome in the practice of many specialists, including of dispensary component, is the important and vital problem. In the treatment of pain syndrome by effective and safe preparations appear the selective inhibitors of cyclooxygenase, representative of which is the nimesulid. Being inhibitor cyclooxygenase -2 it, although it does not exceed traditional nonselective non-steroid anti-inflammatory drugs on its activity, they ensure greater safety of application in patients both with the sharp surgical and with the chronic somatic pathology. This survey makes it possible to draw the conclusion that Nimesulid is the preparation of selection in the prehospital and hospital stage in patients with the acute and chronic pain syndromes, especially in patients with the komorbid conditions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нимесулид</kwd><kwd>Найз</kwd><kwd>хронический и острый болевой синдром</kwd><kwd>коморбидность</kwd><kwd>nimesulid</kwd><kwd>nise</kwd><kwd>acute and chronic pain syndromes</kwd><kwd>komorbid conditions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">BLondeLL RD, Azadfard M, Wisnewski AM. 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