asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/akh2025-044asurgery-597Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCE | PRACTICEПрименение скаффолд-технологий с целью оптимизации заживления кожных ранThe use of scaffold technologies to optimize the healing of skin woundshttps://orcid.org/0009-0007-3244-2611МироновМ. М.MironovM. M.

Миронов Михаил Михайлович, аспирант кафедры «Хирургия»,

440000, Пенза, ул. Лермонтова, д. 3

Mikhail M. Mironov, Postgraduate Student of the Department of Surgery,

3, Lermontov St., Penza, 440000

mhlmironovm@gmail.comhttps://orcid.org/0000-0002-3334-8244СергацкийК. И.SergatskiyK. I.

Сергацкий Константин Игоревич, д.м.н., доцент, профессор кафедры «Хирургия», 

440000, Пенза, ул. Лермонтова, д. 3

Konstantin I. Sergatskiy, Dr. Sci. (Med.), Associate Professor, Professor of Department of Surgery,

3, Lermontov St., Penza, 440000

sergatsky@bk.ruhttps://orcid.org/0000-0002-9927-580XНикольскийВ. И.NikolskyV. I.

Никольский Валерий Исаакович, д.м.н., профессор, профессор кафедры «Хирургия», 

440000, Пенза, ул. Лермонтова, д. 3

Valery I. Nikolsky, Dr. Sci. (Med.), Professor, Professor of Department of Surgery,

3, Lermontov St., Penza, 440000

nvi61@ya.ruhttps://orcid.org/0000-0001-9789-5194РомановаВ. С.RomanovaV. S.

Романова Валерия Сергеевна, ординатор кафедры «Хирургия»,

440000, Пенза, ул. Лермонтова, д. 3

Valeria S. Romanova, Resident of Department of Surgery,

3, Lermontov St., Penza, 440000

valerochka.romanova.00@bk.ruhttps://orcid.org/0000-0003-4413-5524ШабровА. В.ShabrovA. V.

Шабров Александр Валерьевич, к.м.н., доцент, доцент кафедры «Хирургия», 

440000, Пенза, ул. Лермонтова, д. 3

Alexandr V. Shabrov, Cand. Sci. (Med.), Associate Professor of Department of Surgery,

3, Lermontov St., Penza, 440000

alexundead12@yandex.ruhttps://orcid.org/0000-0001-9246-2824ЗахаровА. Д.ZakharovA. D.

Захаров Артем Дмитриевич, к.м.н., ассистент кафедры «Хирургия», 

440000, Пенза, ул. Лермонтова, д. 3

Artem D. Zakharov, Cand. Sci. (Med.), Associate Professor of Department of Surgery,

3, Lermontov St., Penza, 440000

dart_wood@mail.ruПензенский государственный университетРоссияPenza State UniversityRussian Federation202525112025222234242Copyright © Миронов М.М., Сергацкий К.И., Никольский В.И., Романова В.С., Шабров А.В., Захаров А.Д., 20252025Миронов М.М., Сергацкий К.И., Никольский В.И., Романова В.С., Шабров А.В., Захаров А.Д.Mironov M.M., Sergatskiy K.I., Nikolsky V.I., Romanova V.S., Shabrov A.V., Zakharov A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/597

Лечение хронических ран и управление раневым процессом представляют собой тяжелое бремя для мирового здравоохранения, составляя около 3% от общих расходов государств на медицину. Текущие терапевтические стратегии, используемые медицинскими учреждениями, с трудом справляются с эффективным регулированием лечения ран, что приводит к длительному пребыванию пациентов в стационаре. Серьезность этой ситуации усугубляется постоянным ростом факторов риска, связанных с развитием хронических ран. Поэтому необходимо исследовать лечебные решения, способные перезапустить процесс заживления, сосредоточившись на конкретных механизмах, участвующих в репарации ран. В статье рассматриваются актуальные аспекты улучшения процессов заживления кожных ран с использованием скаффолдов. Статья предлагает обзор современных подходов по улучшению регенерации кожных тканей с использованием скаффолд-технологий. В настоящее время скаффолд-технологии применяют в различных направлениях регенеративной медицины. Несомненно, что эффективность данных технологий связана с их особенностями по обеспечению механической поддержки для воспроизведения потенциального каркаса раневого дефекта. Для оценки таких возможностей необходимым является изучение реакции тканей реципиента на интеграцию матрикса в условиях in vivo и определение закономерностей образования волокон коллагена. Были проанализированы зарубежные и отечественные источники через поисковые системы PubMed® и elibrary.ru за последние годы. Обзор охватывает широкий спектр проблем, начиная с общих принципов заживления ран и заканчивая детальным описанием различных типов скаффолдов, затрагивая все ключевые аспекты скаффолд-технологий. Детально проанализированы различные типы скаффолдов, их состав, свойства и преимущества при использовании для улучшения механизмов регенерации кожи.

Chronic wound care and wound healing management are a global public health burden that accounts for approximately 3% of total healthcare expenditure. Current therapeutic strategies used by healthcare institutions struggle to effectively handle the wound treatment, which results in long-term hospital stays. The gravity of the situation is compounded by the continuous growth of risk factors associated with chronic wound development. Therefore, it is necessary to investigate the treatment solutions that can restart wound healing by targeting specific mechanisms involved in wound repair. The article discusses topical issues of the improvement of skin wound healing by using scaffolds. The authors provide a review of current advancements in skin tissue regeneration, highlighting scaffold technologies. Today, scaffold technologies is an essential tool in different areas of regenerative medicine. The efficiency of these technologies is undoubtedly associated with their specific mechanisms aimed at providing mechanical support to reproduce the potential wound defect scaffold. Assessment of such potential requires studying the reaction of recipient tissues to matrix integration in vivo and determining the patterns of collagen fiber formation. We have analysed data from foreign and domestic sources using the search engines PubMed® and elibrary.ru over the past years. The review covers a broad spectrum of issues ranging from general principles of wound healing to a detailed description of various types of scaffolds, addressing all the key aspects of scaffold technologies. Detailed review of different types of scaffolds, their composition, properties and benefits when used to improve skin regeneration mechanisms is provided.

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The authors declare that there are no conflicts of interest present.