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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">asurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Амбулаторная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8741</issn><issn pub-type="epub">2782-2591</issn><publisher><publisher-name>ООО «ГРУППА РЕМЕДИУМ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/akh2024-046</article-id><article-id custom-type="elpub" pub-id-type="custom">asurgery-484</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБМЕН ОПЫТОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXCHANGE OF EXPERIENCE | PRACTICE</subject></subj-group></article-categories><title-group><article-title>Случай из практики: нетипичные проявления вульварного варикоза во время беременности</article-title><trans-title-group xml:lang="en"><trans-title>Atypical manifestations of vulvar varicose veins during pregnancy: A case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3811-5156</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дженина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhenina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дженина Ольга Вадимовна, к.м.н., врач-флеболог </p><p>117447, Россия, Москва, ул. Дмитрия Ульянова, д. 31 </p></bio><bio xml:lang="en"><p>Olga V. Dzhenina, Cand. Sci. (Med.), Phlebologist</p><p>31, Dmitry Ulyanov St., Moscow, 117447, Russia </p></bio><email xlink:type="simple">dzhenina@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3940-0787</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богачев</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogachev</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богачев Вадим Юрьевич, д.м.н., хирург-флеболог; профессор кафедры факультетской хирургии №2 </p><p>117447, Россия, Москва, ул. Дмитрия Ульянова, д. 31</p><p>117997, Россия, Москва, ул. Островитянова, д. 1 </p></bio><bio xml:lang="en"><p>Vadim Yu. Bogachev, Dr. Sci. (Med.), Scientific Supervisor; Professor of the Department of Faculty Surgery No. 2</p><p>31, Dmitry Ulyanov St., Moscow, 117447, Russia</p><p>1, Ostrovityanov St., Moscow, 117997, Russia </p></bio><email xlink:type="simple">vadim.bogachev63@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый флебологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Phlebological Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый флебологический центр;&#13;
Российский национальны исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Phlebological Center;&#13;
Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2024</year></pub-date><volume>21</volume><issue>2</issue><fpage>201</fpage><lpage>207</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дженина О.В., Богачев В.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Дженина О.В., Богачев В.Ю.</copyright-holder><copyright-holder xml:lang="en">Dzhenina O.V., Bogachev V.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.a-surgeon.ru/jour/article/view/484">https://www.a-surgeon.ru/jour/article/view/484</self-uri><abstract><p>Встречаемость варикозного расширения вен вульвы (ВРВВ) во время беременности составляет от 4 до 22%. Принято считать, что ВРВВ во время беременности протекает в большинстве случаев бессимптомно, поэтому симптомным формам уделяется мало внимания, особенно в случаях, когда ВРВВ имитирует собой образование мягких тканей или сопровождается воспалительными явлениями. В статье представлено два клинических случая нетипичных проявлений вульварного варикоза у беременных. Основными жалобами являлись зуд, чувство жжения и отек вульвы, изменение объема выделений из половых органов, что первоначально было расценено как проявления кандидозного вульвовагинита, в т. ч. в сочетании с бактериальным вагинозом. Но местная и системная терапия натамицином в первом случае и неоднократные курсы местной терапии комбинацией неомицина, тернидазола и нистатина с одновременным системным применением метронидазола во втором случае не купировала симптомы. При осмотре у обеих беременных было выявлено ВРВВ. Проведение флеботропной терапии диосмином 600 мг привело к снижению выраженности зуда, уменьшению отека, исчезновению жжения. Негативного влияния диосмина на течение беременности и родов, здоровье новорожденных отмечено не было. Представленные случаи наглядно демонстрируют влияние нетипичной симптоматики ВРВВ на гипердиагностику инфекционно-воспалительных заболеваний вульвы, связанный с этим неадекватный выбор медикаментозной терапии, что в результате приводит к сохранению жалоб, снижению качества жизни беременной и увеличивает риск побочных и нежелательных явлений в процессе лечения. Целесообразно учитывать вероятность вклада ВРВВ при появлении у беременных жалоб на зуд и жжение, отек вульвы, особенно при отсутствии лабораторного подтверждения вагинального кандидоза и/или бактериального вагиноза и упорно рецидивирующей симптоматики на фоне антимикотической, антибактериальной и противовоспалительной терапии. Представляется перспективным использование диосмина в качестве пробной терапии при высокой вероятности венозного генеза подобных симптомов.</p></abstract><trans-abstract xml:lang="en"><p>During pregnancy, the rate of vulvar varicose veins (VVVs) is 4 to 22%. It is commonly believed that VVVs is mostly asymptomatic during pregnancy in the prevailing majority of cases, that’s why little attention is paid to the symptomatic forms, especially in cases where VVVs mimic the soft tissue formation or are accompanied by inflammatory events. The article presents two clinical cases of atypical manifestations of VVVs in pregnant women. The key complaints included itching, burning sensation and swelling in the vulva, changes in the volume of vaginal discharge, which were initially considered as manifestations of vulvovaginal candidiasis (VVC) and combined with bacterial vaginosis. However, the symptoms were not relieved after local and systemic therapy with natamycin in the first case and repeated courses of local therapy with neomycin combined with ternidazole and nystatin accompanied by the systemic use of metronidazole in the second case. The examination findings showed VVVs in both pregnant women. The use of phlebotropic therapy with diosmin 600 mg resulted in a reduction in itching severity, a decrease in swelling, and disappearance of burning sensation. No negative effects of diosmin on the course of pregnancy and childbirth, or the well-being of newborns were observed. Both cases clearly demonstrate the impact of atypical VVV symptoms on the overdiagnosis of infectious and inflammatory diseases of the vulva, and inadequate choice of pharmacological therapy associated with that, ultimately leading to the persistence of complaints, decreased quality of life in pregnant woman and increased risk of side and adverse effects during treatment. It seems appropriate to consider the probability of contribution of VVVs when pregnant women complain about itching, burning sensation and swelling of the vulva, especially in the absence of positive laboratory results of vaginal candidiasis and/or bacterial vaginosis and in the presence of persistently recurring symptoms on antifungal, antibacterial and antiinflammatory therapy. The use of diosmin as a trial therapy appears promising if there is a high probability that such symptoms originate from venous diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипердиагностика</kwd><kwd>инфекционно-воспалительные заболевания вульвы</kwd><kwd>антимикотическая терапия</kwd><kwd>антибактериальная терапия</kwd><kwd>противовоспалительная терапия</kwd><kwd>флеботропная терапия</kwd><kwd>диосмин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>overdiagnosis</kwd><kwd>infectious and inflammatory diseases of the vulva</kwd><kwd>antifungal therapy</kwd><kwd>antibacterial therapy</kwd><kwd>antiinflammatory therapy</kwd><kwd>phlebotropic therapy</kwd><kwd>diosmin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Risner V, McColgan Y, Salazar G. Interventional Treatment of Labial Varices. 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