asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/1995-1477-2022-19-2-119-126asurgery-315Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCE | PRACTICEСравнительная оценка эффективности применения гелей венотонизирующего действияComparative evaluation of the effectiveness of phlebotonic gelshttps://orcid.org/0000-0002-5595-8182ПоздняковД. И.PozdnyakovD. I.

Поздняков Дмитрий Игоревич - доцент кафедры фармакологии с курсом клинической фармакологии.

357532, Пятигорск, проспект Калинина, д. 11

Dmitryi I. Pozdnyakov - Associate Professor of the Department of Pharmacology with a Course in Clinical Pharmacology.

11, Kalinin Ave., Pyatigorsk, 357532

pozdniackow.dmitry@yandex.ruhttps://orcid.org/0000-0002-1184-946XШабановаН. Б.ShabanovaN. B.

Шабанова Наталья Борисовна - старший преподаватель кафедры фармакологии с курсом клинической фармакологии.

357532, Пятигорск, проспект Калинина, д. 11

Natalia B. Shabanova - Senior Lecturer of the Department of Pharmacology with a Course in Clinical Pharmacology.

11, Kalinin Ave., Pyatigorsk, 357532

vahlushina@mail.ruhttps://orcid.org/0000-0003-0294-2926ГеращенкоА. Д.GerashchenkoA. D.

Геращенко Анастасия Дмитриевна - доцент кафедры фармакологии с курсом клинической фармакологии.

357532, Пятигорск, проспект Калинина, д. 11

Anastasia D. Gerashchenko - Associate Professor of the Department of Pharmacology with the Course of Clinical Pharmacology.

11, Kalinin Ave., Pyatigorsk, 357532

anastasia_gerashchenko@mail.ruhttps://orcid.org/0000-0002-1756-0026СаркисянК. Х.SarkisyanK. K.

Саркисян Кристина Хореновна - доцент кафедры фармакологии с курсом клинической фармакологии.

357532, Пятигорск, проспект Калинина, д. 11

Kristina K. Sarkisyan - Associate Professor of the Department of Pharmacology with a Course in Clinical Pharmacology.

11, Kalinin Ave., Pyatigorsk, 357532

kristyfarm@rambler.ruПятигорский медико-фармацевтический институт – филиал Волгоградского государственного медицинского университетаРоссияPyatigorsk Medical and Pharmaceutical Institute – Branch of the Volgograd State Medical UniversityRussian Federation202219112022192119126Copyright © Поздняков Д.И., Шабанова Н.Б., Геращенко А.Д., Саркисян К.Х., 20222022Поздняков Д.И., Шабанова Н.Б., Геращенко А.Д., Саркисян К.Х.Pozdnyakov D.I., Shabanova N.B., Gerashchenko A.D., Sarkisyan K.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/315Введение

Введение. Варикозное расширение вен является распространенным заболеванием с хроническим течением и высоким риском развития осложнений и косметических дефектов. В консервативной терапии варикозного расширения вен широкое применение находят препараты венотонизирующего действия.

Цель

Цель. Изучить сравнительную эффективность лекарственных препаратов венотонизирующего действия для местного применения в экспериментальных условиях.

Материалы и методы

Материалы и методы. Варикозное расширение вен моделировали у крыс Wistar путем частичной стриктуры глубокой бедренной вены. Исследуемые препараты наносили курсом 14 дней с момента операции. Оцениваемыми параметрами служили: изменение скорости локального кровотока в коже в динамике и степень сосудистой проницаемости. Скорость локального кровотока оценивали методом ультразвуковой допплерографии. Изменение проницаемости сосудов изучали по степени экстравазации красителя синий Эванса в тесте Майлза. Результаты обрабатывались методами вариационной статистики.

Результаты

Результаты. Проведенное исследование показало, что в условиях экспериментальной хронической венозной недостаточности курсовое применение всех анализируемых лекарственных препаратов приводило к повышению скорости локального кровотока в коже и уменьшению степени сосудистой проницаемости. При этом отмечено, что нанесение на кожу животных исследуемого геля на основе эсцина, гепарина и эссценциальных фосфолипидов приводило к получению достоверно (p < 0,05) меньших показателей проницаемости сосудов относительно крыс, которые получали курсовую терапию гепарин-содержащим гелем; комбинированным косметическим средством, а также гелем на основе троксерутина, гепарина и декспантенола.

Обсуждение

Обсуждение. Полученные результаты свидетельствуют, что применение наружных лекарственных форм комбинированных препаратов венотонизирующего действия способствует регрессу проявлений хронической венозной недостаточности. При этом максимально выраженный эффект отмечен при аппликации исследуемого препарата, что может быть связано с его комплексным составом, включаю щим эссенциальные фосфолипиды, гепарин и эсцин. Известно, что эсцин является флеботоником с высокой степенью чрескожной абсорбции, действие которого значительно потенцируется фосфолипидным компонентом. Выводы. Аппликация комбинированного средства на основе гепарина, эсцина и эссенциальных фосфолипидов обеспечивала оптимальную скорость наступления фармакологического эффекта по сравнению с другими анализируемыми составами.

Introduction

Introduction. Varicose veins are a common disease with a chronic course and a high risk of complications and cosmetic defects. Venotonic drugs are widely used in conservative treatment of varicose veins.

Aim

Aim. To study the comparative efficacy of venotonic drugs for local application in experimental conditions.

Materials and Methods

Materials and Methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied drugs were applied in the course of 14 days from the operation. The assessed parameters were the change of local blood flow velocity in the skin in the dynamics and the degree of vascular permeability. The rate of local blood flow was assessed by Doppler ultrasound. Changes in vascular permeability were studied by the degree of extravasation of Evans blue dye in the Miles test. The results were processed using the methods of variation statistics.

Results

Results. The study showed that under the conditions of experimental chronic venous insufficiency, a course of application of all the analyzed drugs resulted in an increase in the rate of local blood flow in the skin and a decrease in the degree of vascular permeability. It was noted that application of the investigated gel based on escin, heparin and essential phospholipids to the skin of animals resulted in reliably (p < 0,05) lower indices of vascular permeability in comparison with the rats which received a course therapy with the heparin-containing gel; combined cosmetic agent as well as the gel based on troxerutin, heparin and dexpanthenol.

Discussion

Discussion. The results obtained testify that application of external dosage forms of combined venotonic drugs promotes the regression of chronic venous insufficiency manifestations. Maximum evident effect was registered while applying the studied drug, that can be related to its complex composition including essential phospholipids, heparin and aescin. It is known that aescin is a phlebotonic with a high degree of percutaneous absorption, the effect of which is significantly potentiated by the phospholipid component.

Conclusions

Conclusions. The application of the combined product based on heparin, aescin and essential phospholipids provided an optimum rate of onset of pharmacological effect compared to the other analysed compositions.

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The authors declare that there are no conflicts of interest present.