asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/1995-1477-2022-19-1-147-156asurgery-290Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCE | PRACTICEСовременные маркеры воспалительного процесса в хирургической практикеModern markers of inflammatory process in surgical practicehttps://orcid.org/0000-0003-4213-5379МорозовА. М.MorozovA. M.

Морозов Артем Михайлович, к.м.н., доцент кафедры общей хирургии

170100, Тверь, ул. Советская, д. 4

Artem M. Morozov, Cand. Sci. (Med.), Associate Professor, Department of General Surgery

4, Sovetskaya St., Tver, 170100

ammorozovv@gmail.comhttps://orcid.org/0000-0002-9657-8063СергеевА. Н.SergeevA. N.

Сергеев Алексей Николаевич, д.м.н., доцент, заведующий кафедрой общей хирургии

170100, Тверь, ул. Советская, д. 4

Alexey N. Sergeev, Dr. Sci. (Med.), Associate Professor, Head of the Department of General Surgery

4, Sovetskaya St., Tver, 170100

https://orcid.org/0000-0002-3145-9776ЖуковС. В.ZhukovS. V.

Жуков Сергей Владимирович, д.м.н., заведующий кафедрой скорой помощи и медицины катастроф

170100, Тверь, ул. Советская, д. 4

Sergey V. Zhukov, Dr. Sci. (Med.), Professor, Head of the Department of Ambulance and Disaster Medicine

4, Sovetskaya St., Tver, 170100

https://orcid.org/0000-0003-4564-4777НовиковаН. С.NovikovaN. S.

Новикова Надежда Сергеевна, студентка 6-го курса

170100, Тверь, ул. Советская, д. 4

Nadezhda S. Novikova, 6th Year Student

4, Sovetskaya St., Tver, 170100

БелякМ. А.BelyakM. A.

Беляк Мария Александровна, студентка 4-го курса лечебного факультета

170100, Тверь, ул. Советская, д. 4

Maria A. Belyak, 4th Year Student of the Faculty of General Medicine

4, Sovetskaya St., Tver, 170100

Тверской государственный медицинский университетРоссияTver State Medical UniversityRussian Federation202220052022191147156Copyright © Морозов А.М., Сергеев А.Н., Жуков С.В., Новикова Н.С., Беляк М.А., 20222022Морозов А.М., Сергеев А.Н., Жуков С.В., Новикова Н.С., Беляк М.А.Morozov A.M., Sergeev A.N., Zhukov S.V., Novikova N.S., Belyak M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/290 

 

Введение

Введение. В настоящее время одной из актуальных проблем в хирургии является поиск новых маркеров воспалительного процесса для определения прогноза заболевания, обоснования необходимости хирургического вмешательства и для оценки эффективности лечения.

Цель исследования

Цель исследования. Оценить возможности и перспективы применения современных маркеров воспалительного процесса в практике врача-хирурга.

Материалы и методы

Материалы и методы. В ходе настоящего исследования были проанализированы актуальные источники отечественной и зарубежной литературы по вопросу применения и возможностей использования современных маркеров воспалительного процесса в различных областях медицины. Информация была собрана из базы данных Science Direct, Cyberleninka.ru, PubMed.

Результаты

Результаты. Белки острой фазы, как маркеры воспаления, являются ценным инструментом в диагностике, лечении и прогнозировании воспалительных заболеваний, т. к. обладают чувствительностью к системному воспалению. Важными критериями использования биомаркеров воспаления являются низкое число ложноположительных результатов и возможность использования маркера не только как индикатора заболевания, но и для определения тяжести состояния больного. Для того чтобы оценить наличие воспаления в клинических условиях, лаборатории оценивают концентрации различных белков острой фазы в плазме. В настоящее время наиболее актуальными маркерами воспалительных процессов являются С-реактивный белок и гаптоглобин, ранним индикатором воспаления является также пресепсин, фибриноген, сывороточный амилоид А и система комплемента, содержащая ключевые маркеры воспаления. Определение их в практике врача-хирурга позволит прогнозировать исход заболевания и оценивать результаты лечения.

Выводы

Выводы. На данный момент определение маркеров воспаления помогает в прогнозировании заболевания, планировании тактики лечения, оценке эффективности терапии в послеоперационном периоде и ранней диагностике угрожающих жизни состояний. Последние исследования показали, что белки острой фазы не только играют роль в явлениях воспаления, но и повышают риск развития сердечно-сосудистых заболеваний, играют роль в атерогенезе, неопластических процессах, гемостазе и аутоиммунных процессах.

Introduction

Introduction. Currently, one of the important problems in surgery is the search for new markers of the inflammatory process to determine the prognosis of the disease, substantiate the need for surgical intervention and to assess the effectiveness of treatment.

Aim

Aim. To evaluate the possibilities and prospects of using modern markers of the inflammatory process in the practice of a surgeon.

Materials and methods

Materials and methods. In the course of the present investigation we analyzed relevant sources of domestic and foreign literature on the topic of application and possibilities of use of modern inflammatory process markers in various fields of medicine. Information was collected from databases of ScienceDirect, Cyberleninka.ru, and PubMed.

Results

Results. Acute phase proteins, as markers of inflammation, are valuable tools in the diagnosis, treatment and prognosis of inflammatory diseases, as they are sensitive to systemic inflammation. Important criteria for the use of biomarkers of inflammation are: a low number of false positive results and the possibility of using the marker not only as an indicator of the disease, but also to determine the severity of the patient’s condition. In order to assess the presence of inflammation in clinical conditions, laboratories evaluate the concentrations of various acute phase proteins in plasma. Currently, the most relevant markers of inflammatory processes are: C-reactive protein; haptoglobin; presepsin is also an early indicator of inflammation; fibrinogen; serum amyloid A; a complement system containing key markers of inflammation. Determining them in the surgeon’s practice will allow you to predict the outcome of the disease and evaluate the results of treatment.

Conclusion

Conclusion. At the moment, the determination of inflammatory markers helps in predicting the disease, planning treatment tactics, evaluating the effectiveness of therapy after surgery and in earlier diagnosis of severe conditions.

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The authors declare that there are no conflicts of interest present.