asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/1995-1477-2022-19-1-60-67asurgery-282Research ArticleОРТОПЕДИЯORTHOPEDICSОстеоартрит: современные возможности терапииOsteoarthritis: modern possibilities of therapyhttps://orcid.org/0000-0003-3024-9483ФилатоваЮ. С.FilatovaYu. S.

Филатова Юлия Сергеевна, к.м.н., доцент кафедры терапии имени Е.Н. Дормидонтова Института последипломного образования

150000, Ярославль, ул. Революционная, д. 5

Yulia S. Filatova, Cand. Sci. (Med.), Associate Professor of the Department of Therapy named after E.N. Dormidontov, Instituteof Postgraduate Education

5, Revolutsionnaya St., Yaroslavl, 150000

y.s.filatova@mail.ruhttps://orcid.org/0000-0001-6278-374XИльинМ. В.IlyinM. V.

Ильин Михаил Витальевич, д.м.н., доцент, заведующий кафедрой терапии имени Е.Н. Дормидонтова Института последипломного образования

150000, Ярославль, ул. Революционная, д. 5

Mikhail V. Ilyin, Dr. Sci. (Med.), Associate Professor, Head of the Department of Therapy named after E.N. Dormidontov

5, Revolutsionnaya St., Yaroslavl, 150000

https://orcid.org/0000-0002-9347-1551СоловьевИ. Н.SolovievI. N.

Соловьев Игорь Николаевич, к.м.н., доцент кафедры травматологии и ортопедии 

150000, Ярославль, ул. Революционная, д. 5

Igor N. Soloviev, Cand. Sci. (Med.), Associate Professor, Department of Traumatology and Orthopedics

5, Revolutsionnaya St., Yaroslavl, 150000

Ярославский государственный медицинский университетРоссияYaroslavl State Medical UniversityRussian Federation2022200520221916067Copyright © Филатова Ю.С., Ильин М.В., Соловьев И.Н., 20222022Филатова Ю.С., Ильин М.В., Соловьев И.Н.Filatova Y.S., Ilyin M.V., Soloviev I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/282

В статье обсуждаются вопросы терапии остеоартрита (ОА). В последние десятилетия представления о патогенезе ОА претерпели значительные изменения. Если на заре изучения ОА представлялся как дегенеративный процесс, связанный с возрастом, то в настоящее время, когда стали известны некоторые иммунологические и генетические аспекты заболевания, представление о патогенезе ОА изменилось. В настоящий момент существуют клинические рекомендации, разработанные профессиональными сообществами, в которых определены подходы к диагностике и лечению пациентов с ОА. В России Ассоциацией ревматологов и травматологов-ортопедов в 2021 г. были разработаны клинические рекомендации по ведению пациентов с гонартрозом и коксартрозом, но в настоящее время ни в одной из рекомендаций по лечению не выработано четкого консенсуса относительно применения нутрицевтиков и биологически активных добавок. В то же время опубликованные исследования растительных и ботанических нутрицевтиков, разработанных из натуральных продуктов, продемонстрировали многообещающие данные об эффективности по сравнению с препаратами плацебо и большой потенциал для лечения пациентов с ОА. По данным исследования, проведенного N.E. Lane et al., пациенты с ОА регулярно используют добавки, а также безрецептурные продукты в сочетании с рецептурными препаратами, и вероятность использования рецептурных продуктов учащается с увеличением длительности и тяжести ОА. При этом в настоящее время недостаточно знаний и предоставлений о возможностях дополнительного применения нутрицевтиков в лечении пациентов. В статье рассматривается состав биологически активной добавки, обладающей противовоспалительным, антикатаболическим и антипролиферативным действием, которая может рассматриваться как дополнение к терапии нестероидными противовоспалительными препаратами, хондроитина сульфатом, глюкозамина сульфатом или гидрохлоридом и их комбинацией при ОА. Коллагеновый пептид II типа, куркумин (куркуминоиды 95%), экстракт черного перца (пиперин) и экстракт босвеллии пильчатой в клинических исследованиях продемонстрировали эффективность и безопасность при лечении пациентов с ОА. Также в ряде исследований обнаружили ряд плеойтропных эффектов. Такие эффекты, как противовоспалительные, нейропротективные, иммуномодулирующие, кардиопротективные и противоопухолевые, будут важны пациентам с коморбидностью.

The article discusses the treatment of osteoarthritis (OA). In recent decades, ideas about the pathogenesis of OA have undergone significant changes. If at the dawn of the study OA was presented as a degenerative process associated with age, now that some immunological and genetic aspects of the disease have become known, the idea of the pathogenesis of OA has changed. Currently, there are clinical guidelines developed by professional communities that define approaches to the diagnosis and treatment of patients with OA. In Russia, the Association of Rheumatologists and Orthopedic Traumatologists in 2021 developed clinical guidelines for the management of patients with gonarthrosis and coxarthrosis, but currently no clear consensus has been developed in any of the treatment recommendations regarding the use of nutraceuticals and dietary supplements. While according to published studies of plant and botanical nutraceuticals developed from natural products, promising data on efficacy compared to placebo drugs and their potential for the treatment of patients with OA have been demonstrated. According to a study conducted by N.E. Lane et al., patients with OA regularly use supplements, as well as over-the-counter products in combination with prescription drugs, and the likelihood of using prescription products increases with increasing duration and severity of OA. And currently there is not enough knowledge and information about the possibilities of additional use of nutraceuticals in the treatment of patients. The article discusses the composition of the biologically active additive, which has anti-inflammatory, anti-catabolic and antiproliferative effects and can be considered as an addition to NSAIDs, chondroitin sulfate, glycosamine (sulfate or hydrochloride) and their combinations in OA. Type II collagen peptide, curcumin (curcuminoids 95%), black pepper extract (piperine) and Boswellia pilchata extract in clinical studies have demonstrated efficacy and safety in the treatment of patients with OA. A number of studies have also found a number of pleootropic effects. Effects such as anti-inflammatory, neuroprotective, immunomodulatory, cardioprotective and antitumor effects will be important in patients with comorbidity.

остеоартритнутрицевтикипептиды коллагенакуркуминэкстракт босвеллии пильчатойэкстракт черного перцапиперинosteoarthritisnutraceuticalscollagen peptidescurcuminboswellia pilata extractblack pepper extractpiperineReferencesLiem Y., Judge A., Kirwan J., Ourradi K., Li Y., Sharif M. Multivariable logistic and linear regression models for identification of clinically useful biomarkers for osteoarthritis. Sci Rep. 2020;10(1):11328. https://doi.org/10.1038/s41598-020-68077-0.Liem Y., Judge A., Kirwan J., Ourradi K., Li Y., Sharif M. Multivariable logistic and linear regression models for identification of clinically useful biomarkers for osteoarthritis. Sci Rep. 2020;10(1):11328. https://doi.org/10.1038/s41598-020-68077-0.Mukherjee S., Nazemi M., Jonkers I., Geris L. Use of Computational Modeling to Study Joint Degeneration: A Review. Front Bioeng Biotechnol. 2020;8:93. https://doi.org/10.3389/fbioe.2020.00093.Mukherjee S., Nazemi M., Jonkers I., Geris L. Use of Computational Modeling to Study Joint Degeneration: A Review. Front Bioeng Biotechnol. 2020;8:93. https://doi.org/10.3389/fbioe.2020.00093.Галушко Е.А., Большакова Т.Ю., Виноградова И.Б., Иванова О.Н., Лесняк О.М., Меньшикова Л.В. и др. Структура ревматических заболеваний среди взрослого населения России по данным эпидемиологического исследования (предварительные результаты). Научно-практическая ревматология. 2009;47(1):11–17. Режим доступа: https://rsp.mediar-press.net/rsp/article/view/471.Galushko E.A., Bolshakova T.Yu., Vinogradova I.B., Ivanova O.N., Lesnyak O.M., Menshikova L.V. et al. Structure of rheumatic diseases among adult population of Russia according to data of an epidemiological study (preliminary results). Rheumatology Science and Practice. 2009;47(1):11–17. (In Russ.) Available at: https://rsp.mediar-press.net/rsp/article/view/471.Лила А.М., Алексеева Л.И., Телышев К.А. Современные подходы к фенотипированию остеоартрита. Современная ревматология. 2019;13(2):4–8. https://doi.org/10.14412/1996-7012-2019-2-4-8.Lila A.M., Alekseeva L.I., Telyshev K.A. Current approaches to osteoarthritis phenotyping. Sovremennaya Revmatologiya. 2019;13(2):4–8. (In Russ.) https://doi.org/10.14412/1996-7012- 2019-2-4-8.Kolasinski S.L., Neogi T., Hochberg M.C., Oatis C., Guyatt G., Block J. et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020;72(2):149–162. https://doi.org/10.1002/acr.24131.Kolasinski S.L., Neogi T., Hochberg M.C., Oatis C., Guyatt G., Block J. et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020;72(2):149–162. https://doi.org/10.1002/acr.24131.Bruyère O., Honvo G., Veronese N., Arden N.K., Branco J., Curtis E.M. et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337–350. https://doi.org/10.1016/j.semarthrit.2019.04.008.Bruyère O., Honvo G., Veronese N., Arden N.K., Branco J., Curtis E.M. et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337–350. https://doi. org/10.1016/j.semarthrit.2019.04.008.Bannuru R.R., Osani M.C., Vaysbrot E.E., Arden N.K., Bennell K., Bierma-Zeinstra S.M.A. et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578–1589. https://doi.org/10.1016/j.joca.2019.06.011.Bannuru R.R., Osani M.C., Vaysbrot E.E., Arden N.K., Bennell K., Bierma-Zeinstra S.M.A. et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11):1578–1589. https://doi.org/10.1016/j.joca.2019.06.011.Тихилов Р.М., Корнилов Н.Н., Куляба Т.А., Петухов А.И., Сараев А.В., Божкова С.В. и др. Гонартроз: клинические рекомендации. М.; 2021. 78 с. Режим доступа: https://cr.minzdrav.gov.ru/recomend/667_1.Tikhilov R.M., Kornilov N.N., Kulyaba T.A., Petukhov A.I., Saraev A.V., Bozhkova S.V. et al. Gonarthrosis: clinical guidelines. Moscow; 2021. 78 p. (In Russ.) Available at: https://cr.minzdrav.gov.ru/recomend/667_1.Тихилов Р.М., Лила А.М., Кочиш А.Ю., Алексеева Л.И., Шубняков И.И., Денисов А.О. и др. Коксартроз: клинические рекомендации. М.; 2021. 71 с. Режим доступа: https://cr.minzdrav.gov.ru/recomend/666_1.Tikhilov R.M., Lila A.M., Kochish A.Yu., Alekseeva L.I., Shubnyakov I.I., Denisov A.O. Coxarthrosis: clinical guidelines. Moscow; 2021. 71 p. (In Russ.) Available at: https://cr.minzdrav. gov.ru/recomend/666_1.Наумов А.В., Алексеева Л.И. Ведение больных с остеоартритом и коморбидностью в общей врачебной практике: клинические рекомендации. М.; 2016. 40 с. Режим доступа: https://medvestnik.ru/apps/mv/assets/uploads/Статьи/REK-osteo2016.pdf.Naumov A.V., Alekseeva L.I. Management of patients with osteoarthritis and comorbidity in general medical practice: clinical guidelines. Moscow; 2016. 40 p. (In Russ.) Available at: https://medvestnik.ru/apps/mv/assets/uploads/Статьи/REKosteo2016.pdf.Lane N.E., Ivanova J., Emir B., Mobasheri A., Jensen M.G. Characterization of individuals with osteoarthritis in the United States and their use of prescription and over-thecounter supplements. Maturitas. 2021;145:24–30. https://doi.org/10.1016/j.maturitas.2020.12.001.Lane N.E., Ivanova J., Emir B., Mobasheri A., Jensen M.G. Characterization of individuals with osteoarthritis in the United States and their use of prescription and over-thecounter supplements. Maturitas. 2021;145:24–30. https://doi.org/10.1016/j.maturitas.2020.12.001.Santini A., Novellino E. To Nutraceuticals and Back: Rethinking a Concept. Foods. 2017;6(9):74. https://doi.org/10.3390/foods6090074.Santini A., Novellino E. To Nutraceuticals and Back: Rethinking a Concept. Foods. 2017;6(9):74. https://doi.org/10.3390/ foods6090074.Wang A., Leong D.J., Cardoso L., Sun H.B. Nutraceuticals and osteoarthritis pain. Pharmacol Ther. 2018;187:167–179. https://doi.org/10.1016/j.pharmthera.2018.02.015.Wang A., Leong D.J., Cardoso L., Sun H.B. Nutraceuticals and osteoarthritis pain. Pharmacol Ther. 2018;187:167–179. https://doi.org/10.1016/j.pharmthera.2018.02.015.Liu X., Machado G.C., Eyles J.P., Ravi V., Hunter D.J. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167–175. https://doi.org/10.1136/bjsports-2016-097333.Liu X., Machado G.C., Eyles J.P., Ravi V., Hunter D.J. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167–175. https://doi.org/10.1136/bjsports-2016-097333.Liu X., Eyles J., McLachlan A.J., Mobasheri A. Which supplements can I recommend to my osteoarthritis patients? Rheumatology (Oxford). 2018;57(4 Suppl.):iv75–iv87. https://doi.org/10.1093/rheumatology/key005.Liu X., Eyles J., McLachlan A.J., Mobasheri A. Which supplements can I recommend to my osteoarthritis patients? Rheumatology (Oxford). 2018;57(4 Suppl.):iv75–iv87. https://doi.org/10.1093/rheumatology/key005.Дыдыкина И.С., Коваленко П.С., Меньшикова Л.В. Клиническая эффективность биологически активной добавки Картилокс при остеоартрите. Научно-практическая ревматология. 2021;59(4):450–454. https://doi.org/10.47360/1995-4484-2021-450-454Dydykina I.S., Kovalenko P.S., Menshikova L.V. Clinical efficacy of dietary supplement Cartilox in osteoarthritis. Rheumatology Science and Practice. 2021;59(4):450–454. (In Russ.) https://doi.org/10.47360/1995-4484-2021-450-454.Elango J., Robinson J., Zhang J., Bao B., Ma N., de Val J.E.M.S., Wu W. Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK-Runx2. Cells. 2019;8(5):446. https://doi.org/10.3390/cells8050446.Elango J., Robinson J., Zhang J., Bao B., Ma N., de Val J.E.M.S., Wu W. Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK-Runx2. Cells. 2019;8(5):446. https://doi.org/10.3390/cells8050446.Elango J., Selvaganapathy P.R., Lazzari G., Bao B., Wenhui W. Biomimetic collagen-sodium alginate-titanium oxide (TiO2) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration. Int J Biol Macromol. 2020;163:9–18. https://doi.org/10.1016/j.ijbiomac.2020.06.173.Elango J., Selvaganapathy P.R., Lazzari G., Bao B., Wenhui W. Biomimetic collagen-sodium alginate-titanium oxide (TiO2) 3D matrix supports differentiated periodontal ligament fibroblasts growth for periodontal tissue regeneration. Int J Biol Macromol. 2020;163:9–18. https://doi.org/10.1016/j. ijbiomac.2020.06.173.Litowczenko J., Woźniak-Budych M.J., Staszak K., Wieszczycka K., Jurga S., Tylkowski B. Milestones and current achievements in development of multifunctional bioscaffolds for medical application. Bioact Mater. 2021;6(8):2412–2438. https://doi.org/10.1016/j.bioactmat.2021.01.007.Litowczenko J., Woźniak-Budych M.J., Staszak K., Wieszczycka K., Jurga S., Tylkowski B. Milestones and current achievements in development of multifunctional bioscaffolds for medical application. Bioact Mater. 2021;6(8):2412–2438. https://doi.org/10.1016/j.bioactmat.2021.01.007.Jeevithan E., Jingyi Z., Bao B., Shujun W., JeyaShakila R., Wu W. Biocompatibility assessment of type-II collagen and its polypeptide for tissue engineering: Effect of collagen’s molecular weight and glycoprotein content on tumor necrosis factor (Fas/Apo-1) receptor activation in human acute T-lymphocyte leukemia cell line. RSC Adv. 2016;(6):14236–14246. https://doi.org/10.1039/C5RA24979A.Jeevithan E., Jingyi Z., Bao B., Shujun W., JeyaShakila R., Wu W. Biocompatibility assessment of type-II collagen and its polypeptide for tissue engineering: Effect of collagen’s molecular weight and glycoprotein content on tumor necrosis factor (Fas/Apo-1) receptor activation in human acute T-lymphocyte leukemia cell line. RSC Adv. 2016;(6):14236–14246. https://doi.org/10.1039/C5RA24979A.Wang R., Bao B., Wang S., Elango J., Wu W. Fabrication of Chinese Traditional Medicines incorporated collagen biomaterials for human bone marrow mesenchymal stem cells. Biomed Pharmacother. 2021;139:111659. https://doi.org/10.1016/j.biopha.2021.111659.Wang R., Bao B., Wang S., Elango J., Wu W. Fabrication of Chinese Traditional Medicines incorporated collagen biomaterials for human bone marrow mesenchymal stem cells. Biomed Pharmacother. 2021;139:111659. https://doi.org/10.1016/j.biopha.2021.111659.Elango J., Hou C., Bao B., Wang S., Maté Sánchez de Val J.E., Wenhui W. The Molecular Interaction of Collagen with Cell Receptors for Biological Function. Polymers (Basel). 2022;14(5):876. https://doi.org/10.3390/polym14050876.Elango J., Hou C., Bao B., Wang S., Maté Sánchez de Val J.E., Wenhui W. The Molecular Interaction of Collagen with Cell Receptors for Biological Function. Polymers (Basel). 2022;14(5):876. https://doi.org/10.3390/polym14050876.Benito-Ruiz P., Camacho-Zambrano M.M., CarrilloArcentales J.N., Mestanza-Peralta M.A., Vallejo-Flores C.A., Vargas-López S.V. et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60(2 Suppl.):99–113. https://doi.org/10.1080/09637480802498820.Benito-Ruiz P., Camacho-Zambrano M.M., CarrilloArcentales J.N., Mestanza-Peralta M.A., Vallejo-Flores C.A., Vargas-López S.V. et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60(2 Suppl.):99–113. https://doi. org/10.1080/09637480802498820.Mobasheri A., Mahmoudian A., Kalvaityte U., Uzieliene I., Larder C.E., Iskandar M.M. et al. A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? Curr Rheumatol Rep. 2021;23(11):78. https://doi.org/10.1007/s11926-021-01042-6.Mobasheri A., Mahmoudian A., Kalvaityte U., Uzieliene I., Larder C.E., Iskandar M.M. et al. A White Paper on Collagen Hydrolyzates and Ultrahydrolyzates: Potential Supplements to Support Joint Health in Osteoarthritis? Curr Rheumatol Rep. 2021;23(11):78. https://doi.org/10.1007/s11926-021-01042-6.Sharifi-Rad J., Rayess Y.E., Rizk A.A., Sadaka C., Zgheib R., Zam W. et al. Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Front Pharmacol. 2020;11:01021. https://doi.org/10.3389/fphar.2020.01021.Sharifi-Rad J., Rayess Y.E., Rizk A.A., Sadaka C., Zgheib R., Zam W. et al. Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications. Front Pharmacol. 2020;11:01021. https://doi.org/10.3389/ fphar.2020.01021.D’Cruz D.P., Ferrada M.A. Relapsing Polychondritis and Large-vessel Vasculitis. J Rheumatol. 2020;47(12):1732–1733. https://doi.org/10.3899/jrheum.200083.D’Cruz D.P., Ferrada M.A. Relapsing Polychondritis and Large-vessel Vasculitis. J Rheumatol. 2020;47(12):1732–1733. https://doi.org/10.3899/jrheum.200083.Yeung A.W.K., Horbańczuk M., Tzvetkov N.T., Mocan A., Carradori S., Maggi F. et al. Curcumin: Total-Scale Analysis of the Scientific Literature. Molecules. 2019;24(7):1393. https://doi.org/10.3390/molecules24071393.Yeung A.W.K., Horbańczuk M., Tzvetkov N.T., Mocan A., Carradori S., Maggi F. et al. Curcumin: Total-Scale Analysis of the Scientific Literature. Molecules. 2019;24(7):1393. https://doi.org/10.3390/molecules24071393.Abdelazeem B., Awad A.K., Elbadawy M.A., Manasrah N., Malik B., Yousaf A. et al. The effects of curcumin as dietary supplement for patients with COVID-19: A systematic review of randomized clinical trials. Drug Discov Ther. 2022;16(1):14–22. https://doi.org/10.5582/ddt.2022.01017.Abdelazeem B., Awad A.K., Elbadawy M.A., Manasrah N., Malik B., Yousaf A. et al. The effects of curcumin as dietary supplement for patients with COVID-19: A systematic review of randomized clinical trials. Drug Discov Ther. 2022;16(1):14–22. https://doi.org/10.5582/ddt.2022.01017.Shi H., Wang D., Chen W., Li Y., Si G., Yang T. Quality of Evidence Supporting the Role of Supplement Curcumin for the Treatment of Ulcerative Colitis: An Overview of Systematic Reviews. Gastroenterol Res Pract. 2022:3967935. https://doi.org/10.1155/2022/3967935.Shi H., Wang D., Chen W., Li Y., Si G., Yang T. Quality of Evidence Supporting the Role of Supplement Curcumin for the Treatment of Ulcerative Colitis: An Overview of Systematic Reviews. Gastroenterol Res Pract. 2022:3967935. https://doi.org/10.1155/2022/3967935.Kunnumakkara A.B., Bordoloi D., Padmavathi G., Monisha J., Roy N.K., Prasad S., Aggarwal B.B. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325–1348. https://doi.org/10.1111/bph.13621.Kunnumakkara A.B., Bordoloi D., Padmavathi G., Monisha J., Roy N.K., Prasad S., Aggarwal B.B. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325–1348. https://doi.org/10.1111/ bph.13621.PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Curcumin (Curcuma, Turmeric) and Cancer (PDQ®): Health Professional Version. 2022. In: PDQ Cancer Information Summaries. Bethesda (MD): National Cancer Institute (US); 2002. Available at: https://www.ncbi.nlm.nih.gov/books/NBK568018/.PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Curcumin (Curcuma, Turmeric) and Cancer (PDQ®): Health Professional Version. 2022. In: PDQ Cancer Information Summaries. Bethesda (MD): National Cancer Institute (US); 2002. Available at: https://www.ncbi.nlm.nih. gov/books/NBK568018/.Yin H., Guo Q., Li X., Tang T., Li C., Wang H. et al. Curcumin Suppresses IL-1 Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome. J Immunol. 2018;200(8):2835–2846. https://doi.org/10.4049/jimmunol.1701495.Yin H., Guo Q., Li X., Tang T., Li C., Wang H. et al. Curcumin Suppresses IL-1 Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome. J Immunol. 2018;200(8):2835–2846. https://doi.org/10.4049/ jimmunol.1701495.Burge K., Gunasekaran A., Eckert J., Chaaban H. Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Int J Mol Sci. 2019;20(8):1912. https://doi.org/10.3390/ijms20081912.Burge K., Gunasekaran A., Eckert J., Chaaban H. Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Int J Mol Sci. 2019;20(8):1912. https://doi.org/10.3390/ijms20081912.Yavarpour-Bali H., Ghasemi-Kasman M., Pirzadeh M. Curcumin- - loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine. 2019;14:4449–4460. https://doi.org/10.2147/IJN.S208332.Yavarpour-Bali H., Ghasemi-Kasman M., Pirzadeh M. Curcumin- - loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomedicine. 2019;14:4449–4460. https://doi.org/10.2147/IJN.S208332.Hewlings S.J., Kalman D.S. Curcumin: A Review of Its Effects on Human Health. Foods. 2017;6(10):92. https://doi.org/10.3390/foods6100092.Hewlings S.J., Kalman D.S. Curcumin: A Review of Its Effects on Human Health. Foods. 2017;6(10):92. https://doi.org/10.3390/foods6100092.Chen T., Zhou R., Chen Y., Fu W., Wei X., Ma G. et al. Curcumin ameliorates IL-1β-induced apoptosis by activating autophagy and inhibiting the NF-κB signaling pathway in rat primary articular chondrocytes. Cell Biol Int. 2021;45(5):976–988. https://doi.org/10.1002/cbin.11541.Chen T., Zhou R., Chen Y., Fu W., Wei X., Ma G. et al. Curcumin ameliorates IL-1β-induced apoptosis by activating autophagy and inhibiting the NF-κB signaling pathway in rat primary articular chondrocytes. Cell Biol Int. 2021;45(5):976–988. https://doi.org/10.1002/cbin.11541.Yabas M., Orhan C., Er B., Tuzcu M., Durmus A.S., Ozercan I.H. et al. A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators. Front Immunol. 2021;12:609629. https://doi.org/10.3389/fimmu.2021.609629.Yabas M., Orhan C., Er B., Tuzcu M., Durmus A.S., Ozercan I.H. et al. A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators. Front Immunol. 2021;12:609629. https://doi.org/10.3389/fimmu.2021.609629.Kertia N., Asdie A.H., Rochmah W., Marsetyawan. Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes of patients with osteoarthritis. Acta Med Indones. 2012;44(2):105–113. Available at: http://www.inaactamedica.org/archives/2012/22745140.pdf.Kertia N., Asdie A.H., Rochmah W., Marsetyawan. Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid’s monocytes of patients with osteoarthritis. Acta Med Indones. 2012;44(2):105–113. Available at: http://www.inaactamedica. org/archives/2012/22745140.pdf.Singhal S., Hasan N., Nirmal K., Chawla R., Chawla S., Kalra B.S., Dhal A. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials. 2021;22(1):105. https://doi.org/10.1186/s13063-021-05053-7.Singhal S., Hasan N., Nirmal K., Chawla R., Chawla S., Kalra B.S., Dhal A. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials. 2021;22(1):105. https://doi.org/10.1186/s13063-021-05053-7.Lopresti A.L., Smith S.J., Jackson-Michel S., Fairchild T. An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;14(1):41. https://doi.org/10.3390/nu14010041.Lopresti A.L., Smith S.J., Jackson-Michel S., Fairchild T. An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study. Nutrients. 2021;14(1):41. https://doi.org/10.3390/nu14010041.Al-Yahya A.A.I., Asad M., Sadaby A., Alhussaini M.S. Repeat oral dose safety study of standardized methanolic extract of Boswellia sacra oleo gum resin in rats. Saudi J Biol Sci. 2020;27(1):117–123. https://doi.org/10.1016/j.sjbs.2019.05.010.Al-Yahya A.A.I., Asad M., Sadaby A., Alhussaini M.S. Repeat oral dose safety study of standardized methanolic extract of Boswellia sacra oleo gum resin in rats. Saudi J Biol Sci. 2020;27(1):117–123. https://doi.org/10.1016/j.sjbs.2019.05.010.Khan A.L., Al-Harrasi A., Shahzad R., Imran Q.M., Yun B.W., Kim Y.H. et al. Regulation of endogenous phytohormones and essential metabolites in frankincense-producing Boswellia sacra under wounding stress. Acta Physiol Plant. 2018;40(6):113. https://doi.org/10.1007/s11738-018-2688-6.Khan A.L., Al-Harrasi A., Shahzad R., Imran Q.M., Yun B.W., Kim Y.H. et al. Regulation of endogenous phytohormones and essential metabolites in frankincense-producing Boswellia sacra under wounding stress. Acta Physiol Plant. 2018;40(6):113. https://doi.org/10.1007/s11738-018-2688-6.Al-Harrasi A., Rehman N.U., Khan A.L., Al-Broumi M., Al-Amri I., Hussain J. et al. Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11 – Dihydroxy BA as precursors in biosynthesis of boswellic acids. PLoS ONE. 2018;13(6):e0198666. https://doi.org/10.1371/journal.pone.0198666.Al-Harrasi A., Rehman N.U., Khan A.L., Al-Broumi M., Al-Amri I., Hussain J. et al. Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11 – Dihydroxy BA as precursors in biosynthesis of boswellic acids. PLoS ONE. 2018;13(6):e0198666. https://doi.org/10.1371/ journal.pone.0198666.Li W., Liu J., Fu W., Zheng X., Ren L., Liu S. et al. 3-O-acetyl-11- keto-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Cancer Res. 2018;37(1):132. https://doi.org/10.1186/s13046-018-0805-4.Li W., Liu J., Fu W., Zheng X., Ren L., Liu S. et al. 3-O-acetyl-11- keto-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. J Exp Clin Cancer Res. 2018;37(1):132. https://doi.org/10.1186/s13046-018-0805-4.Schmidt C., Loos C., Jin L., Schmiech M., Schmidt C.Q., Gaafary M.E. et al. Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo. Oncotarget. 2017;8(33):55147–55161. https://doi.org/10.18632/oncotarget.19101.Schmidt C., Loos C., Jin L., Schmiech M., Schmidt C.Q., Gaafary M.E. et al. Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo. Oncotarget. 2017;8(33):55147–55161. https://doi.org/10.18632/oncotarget.19101.Byler K.G., Setzer W.N. Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia OleoGum Resins. Medicines (Basel). 2018;5(3):96. /https://doi.org/10.3390/medicines5030096.Byler K.G., Setzer W.N. Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Boswellia OleoGum Resins. Medicines (Basel). 2018;5(3):96. /https://doi. org/10.3390/medicines5030096.Mahmoud M.F., Diaai A.A., Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail. 2012;34(1):73–82. https://doi.org/10.3109/0886022X.2011.623563.Mahmoud M.F., Diaai A.A., Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail. 2012;34(1):73–82. https://doi.org/10.3109/08 86022X.2011.623563.Kimmatkar N., Thawani V., Hingorani L., Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3–7. https://doi.org/10.1078/094471103321648593.Kimmatkar N., Thawani V., Hingorani L., Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3–7. https://doi.org/10.1078/094471103321648593.Majeed M., Majeed S., Narayanan N.K., Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019;33(5):1457–1468. https://doi.org/10.1002/ptr.6338.Majeed M., Majeed S., Narayanan N.K., Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019;33(5):1457–1468. https://doi.org/10.1002/ ptr.6338.Kulkarni P.D., Damle N.D., Singh S., Yadav K.S., Ghante M.R., Bhaskar V.H. et al. Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee. Drug Metab Pers Ther. 2020;35(2):20200104. https://doi.org/10.1515/dmpt-2020-0104.Kulkarni P.D., Damle N.D., Singh S., Yadav K.S., Ghante M.R., Bhaskar V.H. et al. Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee. Drug Metab Pers Ther. 2020;35(2):20200104. https://doi.org/10.1515/dmpt-2020-0104.Srinivasan K. Antioxidant potential of spices and their active constituents. Crit Rev Food Sci Nutr. 2014;54(3):352–372. https://doi.org/10.1080/10408398.2011.585525.Srinivasan K. Antioxidant potential of spices and their active constituents. Crit Rev Food Sci Nutr. 2014;54(3):352–372. https://doi.org/10.1080/10408398.2011.585525.Smilkov K., Ackova D.G., Cvetkovski A., Ruskovska T., Vidovic B., Atalay M. Piperine: Old Spice and New Nutraceutical? Curr Pharm Des. 2019;25(15):1729–1739. https://doi.org/10.2174/1381612825666190701150803.Smilkov K., Ackova D.G., Cvetkovski A., Ruskovska T., Vidovic B., Atalay M. Piperine: Old Spice and New Nutraceutical? Curr Pharm Des. 2019;25(15):1729–1739. https://doi.org/10.2174/1381612825666190701150803.Adnan M., Nazim Uddin Chy M., Mostafa Kamal A.T.M., Azad M.O.K., Paul A., Uddin S.B. et al. Investigation of the Biological Activities and Characterization of Bioactive Constituents of Ophiorrhiza rugosa var. prostrata (D.Don) & Mondal Leaves through In Vivo, In Vitro, and In Silico Approaches. Molecules. 2019;24(7):1367. https://doi.org/10.3390/molecules24071367.Adnan M., Nazim Uddin Chy M., Mostafa Kamal A.T.M., Azad M.O.K., Paul A., Uddin S.B. et al. Investigation of the Biological Activities and Characterization of Bioactive Constituents of Ophiorrhiza rugosa var. prostrata (D.Don) & Mondal Leaves through In Vivo, In Vitro, and In Silico Approaches. Molecules. 2019;24(7):1367. https://doi. org/10.3390/molecules24071367.Emon N.U., Alam S., Rudra S., Riya S.R., Paul A., Hossen S.M.M. et al. Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum: In vivo, in vitro, and in silico approaches. Food Sci Nutr. 2021;9(2):833–846. https://doi.org/10.1002/fsn3.2047.Emon N.U., Alam S., Rudra S., Riya S.R., Paul A., Hossen S.M.M. et al. Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum: In vivo, in vitro, and in silico approaches. Food Sci Nutr. 2021;9(2):833–846. https://doi.org/10.1002/fsn3.2047.Banerjee S., Katiyar P., Kumar V., Saini S.S., Varshney R., Krishnan V. et al. Black pepper and piperine induce anticancer effects on leukemia cell line. Toxicol Res (Camb). 2021;10(2):169–182. https://doi.org/10.1093/toxres/tfab001.Banerjee S., Katiyar P., Kumar V., Saini S.S., Varshney R., Krishnan V. et al. Black pepper and piperine induce anticancer effects on leukemia cell line. Toxicol Res (Camb). 2021;10(2):169–182. https://doi.org/10.1093/toxres/tfab001.Salehi B., Zakaria Z.A., Gyawali R., Ibrahim S.A., Rajkovic J., Shinwari Z.K. et al. Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. Molecules. 2019;24(7):1364. https://doi.org/10.3390/molecules24071364.Salehi B., Zakaria Z.A., Gyawali R., Ibrahim S.A., Rajkovic J., Shinwari Z.K. et al. Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. Molecules. 2019;24(7):1364. https://doi.org/10.3390/ molecules24071364.Manayi A., Nabavi S.M., Setzer W.N., Jafari S. Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies. Curr Med Chem. 2018;25(37):4918–4928. https://doi.org/10.2174/0929867324666170523120656.Manayi A., Nabavi S.M., Setzer W.N., Jafari S. Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies. Curr Med Chem. 2018;25(37):4918–4928. https://doi.org/10.2174/ 0929867324666170523120656.Rather R.A., Bhagat M. Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities. Front Cell Dev Biol. 2018;6:10. https://doi.org/10.3389/fcell.2018.00010.Rather R.A., Bhagat M. Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities. Front Cell Dev Biol. 2018;6:10. https://doi.org/10.3389/fcell.2018.00010.Turrini E., Sestili P., Fimognari C. Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine. Toxins (Basel). 2020;12(12):747. https://doi.org/10.3390/toxins12120747.Turrini E., Sestili P., Fimognari C. Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine. Toxins (Basel). 2020;12(12):747. https://doi.org/10.3390/toxins12120747.Филатова Ю.С., Соловьев И.Н. Тактика ведения пациентов с остеоартритом: взгляд ревматолога и травматолога-ортопеда. Медицинский совет. 2020;(19):89–97. https://doi.org/10.21518/2079-701X-2020-19-89-97.Filatova Yu.S., Soloviev I.N. Management tactics for patients with osteoarthritis: a joint view of a rheumatologist and an orthopedic traumatologist. Meditsinskiy Sovet. 2020;(19):89–97. (In Russ.) https://doi.org/10.21518/2079-701X-2020-19-89-97.Филатова Ю.С., Соловьев И.Н. Пациент с остеоартритом коленных суставов: тактика ведения в амбулаторных условиях. Медицинский совет. 2021;(2):86–93. https://doi.org/10.21518/2079-701X-2021-2-86-93.Filatova Yu.S., Soloviev I.N. Patients with osteoarthritis of the knee: management in the outpatient setting. Meditsinskiy Sovet. 2021;(2):86–93. (In Russ.) https://doi.org/10.21518/2079-701X-2021-2-86-93.

The authors declare that there are no conflicts of interest present.