<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">asurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Амбулаторная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8741</issn><issn pub-type="epub">2782-2591</issn><publisher><publisher-name>ООО «ГРУППА РЕМЕДИУМ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/1995-1477-2021-18-1-55-70</article-id><article-id custom-type="elpub" pub-id-type="custom">asurgery-229</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГНОЙНЫЕ И ТРОФИЧЕСКИЕ ПОРАЖЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PURULENT AND TROPHIC LESIONS</subject></subj-group></article-categories><title-group><article-title>Язва Марторелла: обзор литературы и собственное клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Martorell’s ulcer: a literature review and own clinical observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4488-9123</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болдин</surname><given-names>Б. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Boldin</surname><given-names>B. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Болдин Борис Валентинович, д.м.н., профессор, заведующий кафедрой факультетской хирургии №2</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Boris V. Boldin, Dr. Sci. (Med.), Professor, head of the Department of Faculty Surgery No. 2</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><email xlink:type="simple">facultysurgery@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голосницкий</surname><given-names>П. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Golosnitskiy</surname><given-names>P. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голосницкий Павел Юрьевич, к.м.н., доцент кафедры  факультетской хирургии №2</p><p>117997, Москва, ул. Островитянова, д. 1;</p><p>119071, Москва, Ленинский проспект, д. 27</p></bio><bio xml:lang="en"><p>Pavel Yu. Golosnitskiy, Cand. Sci. (Med.), Associate Professor,  Department of Faculty Surgery No. 2</p><p>1, Ostrovityanov St., Moscow, 117997;</p><p>27, Leninsky Prospekt, Moscow, 119071</p></bio><email xlink:type="simple">hirurg1978@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3940-0787</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богачёв</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogachev</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богачёв Вадим Юрьевич, д.м.н., профессор кафедры  факультетской хирургии №2</p><p>117997, Москва, ул. Островитянова, д. 1;</p><p>117447, Москва, ул. Дмитрия ульянова, д. 31</p></bio><bio xml:lang="en"><p>Vadim Yu. Bogachev, Dr. Sci. (Med.), Professor, Department of  Faculty Surgery No. 2</p><p>1, Ostrovityanov St., Moscow, 117997;</p><p>31, Dmitry ulyanov St., Moscow, 117447</p></bio><email xlink:type="simple">vadim.bogachev63@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родионов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodionov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Родионов Сергей Васильевич, д.м.н., профессор кафедры  факультетской хирургии №2</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Sergey V. Rodionov, Cand. Sci. (Med.), Professor, Department of  Faculty Surgery No. 2</p><p>1, Ostrovityanov St., Moscow, 117997</p></bio><email xlink:type="simple">facultysurgery@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дизенгоф</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dizengof</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дизенгоф Игорь Михайлович, к.м.н., заведующий 1-м  хирургическим отделением</p><p>119071, Москва, Ленинский проспект, д. 27</p></bio><bio xml:lang="en"><p>Igor M. Dizengof, Cand. Sci. (Med.), head of the 1st Surgical  Department</p><p>27, Leninsky Prospekt, Moscow, 119071</p></bio><email xlink:type="simple">idizengof@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова;&#13;
Центральная клиническая больница святителя Алексия, митрополита Московского Московской патриархии РПЦ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University;&#13;
ANO Central Clinical hospital of the Moscow Patriarchate of St. Alexy of the Russian Orthodox Church</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н.И. Пирогова;&#13;
Первый флебологический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University;&#13;
First Phlebological Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Центральная клиническая больница святителя Алексия, митрополита Московского Московской патриархии РПЦ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ANO Central Clinical hospital of the Moscow Patriarchate of St. Alexy of the Russian Orthodox Church</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>08</day><month>06</month><year>2021</year></pub-date><volume>18</volume><issue>1</issue><fpage>55</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Болдин Б.В., Голосницкий П.Ю., Богачёв В.Ю., Родионов С.В., Дизенгоф И.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Болдин Б.В., Голосницкий П.Ю., Богачёв В.Ю., Родионов С.В., Дизенгоф И.М.</copyright-holder><copyright-holder xml:lang="en">Boldin B.V., Golosnitskiy P.Y., Bogachev V.Y., Rodionov S.V., Dizengof I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.a-surgeon.ru/jour/article/view/229">https://www.a-surgeon.ru/jour/article/view/229</self-uri><abstract><p>Введение. язва Марторелла – это довольно редко встречающаяся патология, возникающая исключительно у пациентов с длительно существующей и плохо контролируемой артериальной гипертензией и продолжающая оставаться одним из малоизученных разделов современной хирургии. Вопросы этиологии, патогенеза и дифференциальной диагностики данного заболевания в настоящее время продолжают вызывать дискуссии. В статье проведен обзор литературы, посвященный этой редкой хирургической патологии, представлено собственное клиническое наблюдение, рассмотрены вопросы диагностики и варианты лечения данного заболевания.Клинический случай. Пациент Ц., 56 лет, при поступлении предъявлял жалобы на наличие не заживающей в течение года трофической язвы на латеральной поверхности нижней трети правой голени с выраженным болевым синдромом, плохо купирующимся приемом ненаркотических анальгетиков. Лечился самостоятельно амбулаторно в поликлиническом отделении и стационарно, проводились курсы реологической терапии, в качестве местной терапии на область язвы использовал широкий спектр перевязочных средств отечественного и иностранного производства. На фоне проводимой комплексной терапии положительного эффекта не отмечено, язва продолжала увеличиваться в размерах. Диагностирована язва Марторелла, принято решение о необходимости проведения курса предоперационной консервативной реологической терапии препаратом PGE1 (ВАП 20 мг), антибиотикотерапии, местной терапии, направленной на максимальное очищение язвы от некротических тканей перед предстоящим плановым оперативным лечением. Выполнена операция: аутодерматопластика трофической язвы правой голени перфорированным кожным лоскутом, продолжено местное лечение язвы с использование повязок с перуанским бальзамом и др. в амбулаторных условиях без участия химических и биологических компонентов из группы антисептиков и стимуляторов заживления. Через два месяца после операции пациент жалоб не предъявляет, болевой синдром в области язвы полностью регрессировал, отека нижней оперированной конечности нет, язва правой голени полностью зажила с формированием стойкого рубца.Заключение. Хирургическое лечение является окончательным и радикальным методом лечения хронической гипертензивной язвы Марторелла и должно проводиться незамедлительно, чтобы свести к минимуму ее распространение и минимизировать болевой синдром.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Martorell’s ulcer is a rather rare pathology that occurs exclusively in patients with long-term and poorly controlled arterial hypertension and continues to be one of the poorly studied areas of modern surgery. There are few reports on the occurrence of this pathology in the medical literature and, as a rule, describe extremely rare clinical cases. The issues of etiology, pathogenesis and differential diagnosis of this disease continue to cause debate. The article provides a review of the literature on this rare surgical pathology, presents its own clinical observation, discusses the issues of diagnosis and treatment options for this disease.Clinical case. A 56-year-old patient was admitted with complaints of a non-healing trophic ulcer on the lateral surface in the lower third of the right leg since one year ago with severe pain syndrome not adequately controlled with non-narcotic analgesics. he received treatment in an outpatient department and in the hospital, underwent courses of rheological therapy to the ulcer region as a local therapy, used a wide range of dressings of domestic and foreign origin. No positive effect was reported on the top of already administered combination therapy, the ulcer continued to increase in size. A Martorell’s ulcer was diagnosed, and a decision was made to provide a course of presurgical conservative rheological therapy with PGE1 (VAP 20 mg), antibiotic therapy, and local therapy aimed at maximal ulcer necrotic tissue clearance before the forthcoming planned surgical treatment. The patient underwent the surgery – autodermatoplasty of the trophic ulcer of the right leg with a mesh graft, continued local treatment of the ulcer using dressings with peruvian balsam and other medications on an outpatient basis without chemical and biological components from the antiseptics and healing stimulants group. Two months after the surgery, the patient had no complaints, the pain syndrome in the ulcer region completely regressed, no edema occurred in the lower operated leg, the right let ulcer completely healed with the formation of a permanent scar.Conclusion. Surgical management is the final and definitive treatment for Martorell’s chronic hypertensive ulcer and should be carried out promptly to minimize the spread of the ulcer and minimize a pain syndrome.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>язва Марторелла</kwd><kwd>гипертоническая ишемическая язва голени</kwd><kwd>гангренозная пиодермия</kwd><kwd>кальцифилаксия</kwd><kwd>хроническая длительно незаживающая язва</kwd><kwd>аутодерматопластика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Martorell’s ulcer</kwd><kwd>hypertensive ischemic ulcer of the leg</kwd><kwd>pyoderma gangrenosum</kwd><kwd>calciphylaxis</kwd><kwd>chronic long-term nonhealing ulcer</kwd><kwd>autodermatoplasty</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vuerstaek J.D., Reeder S.W., Henquet C.J., Neumann H.A. Arteriolosclerotic ulcer of Martorell. J Eur Acad Dermatol Venereol. 2010;24(8):867–874. doi: 10.1111/j.1468-3083.2009.03553.x.</mixed-citation><mixed-citation xml:lang="en">Vuerstaek J.D., Reeder S.W., Henquet C.J., Neumann H.A. Arteriolosclerotic ulcer of Martorell. J Eur Acad Dermatol Venereol. 2010;24(8):867–874. doi: 10.1111/j.1468-3083.2009.03553.x.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Alavi A., Mayer D., Hafner J., Sibbald R.G. Martorell hypertensive Ischemic Leg ulcer: An underdiagnosed Entity©. Adv Skin Wound Care. 2012;25(12):563–572; quiz 573-574. doi: 10.1097/01.ASw.0000423442.08531.fb.</mixed-citation><mixed-citation xml:lang="en">Alavi A., Mayer D., Hafner J., Sibbald R.G. Martorell hypertensive Ischemic Leg ulcer: An underdiagnosed Entity©. Adv Skin Wound Care. 2012;25(12):563–572; quiz 573-574. doi: 10.1097/01.ASw.0000423442.08531.fb.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Андреев Д.Ю., Абрамова Н.В., Блинова М.И., Пинаев Г.П. Эффективность кожной пластики и дермального эквивалента в лечении обширных язв голени смешанного генеза. Вестник хирургии имени И.И. Грекова. 2013;17218(1):104–107. doi: 10.24884/0042-4625-2013-172-1-104-107.</mixed-citation><mixed-citation xml:lang="en">Andreev D.Yu., Abramova N.V., Blinova M.I., Pinaev G.P. Efficacy of Dermoplasty and the Dermal Equivalent in Treatment of Vast Leg ulcers of Mixed Genesis. Vestnik khirurgii imeni I.I. Grekova = Grekov’s Bulletin of Surgery. 2013;17218(1):104–107. (In Russ.) doi: 10.24884/0042-4625-2013-172-1-104-107.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aралова M.В., Глухов A.А. Клинический случай лечения пациентки с язвой Марторелла. Вестник экспериментальной и клинической хирургии. 2014;7(3):265–268. Режим доступа: https://vestnik-surgery.com/index.php/journal/article/view/580/499.</mixed-citation><mixed-citation xml:lang="en">Aralova M.V., Glukhov A.A. Clinical Case of Treatment of the Patient with Martorell’s ulcer. Vestnik eksperimentaʹnoy i klinicheskoy khirurgii = Bulletin of Experimental and Clinical Surgery. 2014;7(3):265–268. (In Russ.) Available at: https://vestnik-surgery.com/index.php/journal/article/view/580/499.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ватутин Н., Фисталь Э., Тарадин Г., Василенко И., Грищенко И., Гончарук М. успешное комбинированное лечение гипертонической язвы голени (язвы Марторелла). Врач. 2018;(2):58–62. doi: 10.29296/25877305-2018-02-14.</mixed-citation><mixed-citation xml:lang="en">Vatutin N., Fistal’ E., Taradin G., Vasilenko I., Grishchenko I., Goncharuk M. Successful Combined Treatment of hypertensive Leg ulcer (Martorell’s ulcer). Vrach = The Doctor. 2018;(2):58– 62. (In Russ.) doi: 10.29296/25877305-2018-02-14.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mansour M, Alavi A. Martorell ulcer: Chronic wound Management and Rehabilitation. Chronic Wound Care Man and Res. 2019;(6):83–88. doi: 10.2147/CwCMR.S172427.</mixed-citation><mixed-citation xml:lang="en">Mansour M, Alavi A. Martorell ulcer: Chronic wound Management and Rehabilitation. Chronic Wound Care Man and Res. 2019;(6):83–88. doi: 10.2147/CwCMR.S172427.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hafner J., Nobbe S., Partsch H., Läuchli S., Mayer D., AmannVesti B. et al. Martorell hypertensive Ischemic Leg ulcer: A Model of Ischemic Subcutaneous Arteriolosclerosis. Arch Dermatol. 2010;146(9):961–968. doi: 10.1001/archdermatol.2010.224.</mixed-citation><mixed-citation xml:lang="en">Hafner J., Nobbe S., Partsch H., Läuchli S., Mayer D., AmannVesti B. et al. Martorell hypertensive Ischemic Leg ulcer: A Model of Ischemic Subcutaneous Arteriolosclerosis. Arch Dermatol. 2010;146(9):961–968. doi: 10.1001/archdermatol.2010.224.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Martorell F. Las ulceras supramaleolares por arteriolitis de las grandes hipertensas = Supramaleolar ulcers Due to Arteriolitis of the Great hypertensive. Actas (Reun Cientif Cuerpo Facul) Inst Policlinico Barcelona. 1945;1:6–9.</mixed-citation><mixed-citation xml:lang="en">Martorell F. Las ulceras supramaleolares por arteriolitis de las grandes hipertensas = Supramaleolar ulcers Due to Arteriolitis of the Great hypertensive. Actas (Reun Cientif Cuerpo Facul) Inst Policlinico Barcelona. 1945;1:6–9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hines E.A. Jr, Farber E.M. Ulcer of the Leg Due to Arteriolosclerosis and Ischemia Occurring in the Presence of hypertensive Disease (hypertensive-Ischemic ulcers). Proc Staff Meet Mayo Clin. 1946;21(18):337–346.</mixed-citation><mixed-citation xml:lang="en">Hines E.A. Jr, Farber E.M. ulcer of the Leg Due to Arteriolosclerosis and Ischemia Occurring in the Presence of hypertensive Disease (hypertensive-Ischemic ulcers). Proc Staff Meet Mayo Clin. 1946;21(18):337–346.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Farber E.M., Hines E.A. Jr, Montgomery H., Craig W. The Arterioles of the Skin in Essential hypertension. J Invest Dermatol. 1947;9(6):285–298. Available at: https://jidonline.org/article/S0022-202x(15)50212-1/pdf.</mixed-citation><mixed-citation xml:lang="en">Farber E.M., Hines E.A. Jr, Montgomery H., Craig W. The Arterioles of the Skin in Essential hypertension. J Invest Dermatol. 1947;9(6):285–298. Available at: https://jidonline.org/article/S0022-202x(15)50212-1/pdf.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chnier B.R., Sheps S.G., Juergens J.L. hypertensive Ischemic ulcer. A Review of 40 Cases. Am J Cardiol. 1966;17(4):560–565. doi: 10.1016/0002-9149(66)90247-5.</mixed-citation><mixed-citation xml:lang="en">Chnier B.R., Sheps S.G., Juergens J.L. hypertensive Ischemic ulcer. A Review of 40 Cases. Am J Cardiol. 1966;17(4):560–565. doi: 10.1016/0002-9149(66)90247-5.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Лазарев С.М. Артериопатии. Поражения и дисфункция капилляров (ангиоригоз или трофоангионевроз). Мир медицины. 2000;(11):25–28.</mixed-citation><mixed-citation xml:lang="en">Lazarev S.M. Arteriopathies. Capillary Lesions and Dysfunction (Angiorigosis or Trophoangioneurosis). Mir meditsiny = The World of Medicine. 2000;(11):25–28. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Graves J.W., Morris J.C., Sheps S.G. Martorell’s hypertensive Leg ulcer: Case Report and Concise Review of the Literature. J Hum Hypertens. 2001;15(4):279–283. doi: 10.1038/sj.jhh.1001154.</mixed-citation><mixed-citation xml:lang="en">Graves J.W., Morris J.C., Sheps S.G. Martorell’s hypertensive Leg ulcer: Case Report and Concise Review of the Literature. J Hum Hypertens. 2001;15(4):279–283. doi: 10.1038/sj.jhh.1001154.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Шевченко Ю.Л., Стойко Ю.М., Рябов А.Л., Козлов Ю.А., Линчак Р.М., Белоусов Е.А. О лечении трофической язвы Марторелла. Вестник Национального медико-хирургического центра имени Н.И. Пирогова. 2010;518(1):128–132. Режим доступа: https://pirogov-vestnik.ru/upload/uf/256/magazine_2010_1.pdf.</mixed-citation><mixed-citation xml:lang="en">Shevchenko Yu.L., Stoyko Yu.M., Ryabov A.L., Kozlov Yu.A., Linchak R.M., Belousov E.A. On the Treatment of Martorell Trophic ulcer. Vestnik Natsional’nogo mediko-khirurgicheskogo tsentra imeni N.I. Pirogova = Bulletin of N.I. Pirogov National Medical and Surgical Center. 2010;518(1):128–132. (In Russ.) Available at: https://pirogov-vestnik.ru/upload/uf/256/magazine_2010_1.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Weber B., Deinsberger J., Hafner J., Beltraminelli H., Tzaneva S., Böhler K. Localization-Mapping of Arteriolosclerotic ulcers of Martorell using Two-Dimensional Computational Rendering Reveals a Predominant Location on the Mid-Lateral Lower Leg. J Eur Acad Dermatol Venereol. 2021;3518(1):e40-e42. doi: 10.1111/jdv.16787.</mixed-citation><mixed-citation xml:lang="en">Weber B., Deinsberger J., Hafner J., Beltraminelli H., Tzaneva S., Böhler K. Localization-Mapping of Arteriolosclerotic ulcers of Martorell using Two-Dimensional Computational Rendering Reveals a Predominant Location on the Mid-Lateral Lower Leg. J Eur Acad Dermatol Venereol. 2021;3518(1):e40-e42. doi: 10.1111/jdv.16787.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Фисталь Э.Я., Ватутин Н.Т., Тарадин Г.Г., Гончарук М.С., Грищенко И.С., Василенко И.В. язвы Марторелла. Вестник дерматологии и венерологии. 2018;94(3):51–55. doi: 10.25208/0042-4609-2018-94-3-51-55.</mixed-citation><mixed-citation xml:lang="en">Fistal E.Ya., Vatutin N.T., Taradin G.G., Goncharuk M.S., Grishchenko I.S., Vasilenko I.V. Martorell ulcers. Vestnik dermatologii i venerologii = Bulletin of Dermatology and Venereology. 2018;94(3):51–55. doi: 10.25208/0042-4609-2018-94-3-51-55.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Malhi H.K., Didan A., Ponosh S., Kumarasinghe S.P. Painful Leg ulceration in a Poorly Controlled hypertensive Patient: A Case Report of Martorell ulcer. Case Rep Dermatol. 2017;918(1):95–102. doi: 10.1159/000468977.</mixed-citation><mixed-citation xml:lang="en">Malhi H.K., Didan A., Ponosh S., Kumarasinghe S.P. Painful Leg ulceration in a Poorly Controlled hypertensive Patient: A Case Report of Martorell ulcer. Case Rep Dermatol. 2017;918(1):95–102. doi: 10.1159/000468977.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Obermayer A., Maier A., Zacherl J., Hitzl W, Steinbacher F. Lateral Fasciectomy Sparing the Superficial Peroneal Nerve with Simultaneous Mesh Graft in Non-healing Lateral Leg ulcers of Diverse Vascular Origins: Surgical Technique, Shortand Long-term Results from 44 Legs. Eur J Vasc Endovasc Surg. 2016;52(2):225–232. doi: 10.1016/j.ejvs.2016.02.023.</mixed-citation><mixed-citation xml:lang="en">Obermayer A., Maier A., Zacherl J., Hitzl W, Steinbacher F. Lateral Fasciectomy Sparing the Superficial Peroneal Nerve with Simultaneous Mesh Graft in Non-healing Lateral Leg ulcers of Diverse Vascular Origins: Surgical Technique, Shortand Long-term Results from 44 Legs. Eur J Vasc Endovasc Surg. 2016;52(2):225–232. doi: 10.1016/j.ejvs.2016.02.023.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lima Pinto A.P., Silva N.A. Jr, Osorio C.T., Rivera L.M., Carneiro S., Ramos-E-Silva M., Gomes Bica B.E. Martorell’s ulcer: Diagnostic and Therapeutic Challenge. Case Rep Dermatol. 2015;7(2):199–206. doi: 10.1159/000430884.</mixed-citation><mixed-citation xml:lang="en">Lima Pinto A.P., Silva N.A. Jr, Osorio C.T., Rivera L.M., Carneiro S., Ramos-E-Silva M., Gomes Bica B.E. Martorell’s ulcer: Diagnostic and Therapeutic Challenge. Case Rep Dermatol. 2015;7(2):199–206. doi: 10.1159/000430884.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Conde Montero E., Guisado Muñoz S., Pérez Jerónimo L., Peral Vazquez A., Montoro Lopez J.J., Hocajada Reales C. et al. Martorell hypertensive Ischemic ulcer Successfully Treated with Punch Skin Grafting. Wounds. 2018;30(2):E9-E12. Available at: https://woundsresearch.com/article/martorellhypertensive-ischemic-ulcer-successfully-treated-punch-skingrafting.</mixed-citation><mixed-citation xml:lang="en">Conde Montero E., Guisado Muñoz S., Pérez Jerónimo L., Peral Vazquez A., Montoro Lopez J.J., Hocajada Reales C. et al. Martorell hypertensive Ischemic ulcer Successfully Treated with Punch Skin Grafting. Wounds. 2018;30(2):E9-E12. Available at: https://woundsresearch.com/article/martorellhypertensive-ischemic-ulcer-successfully-treated-punch-skingrafting.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Duncan H.J., Faris I.B. Martorell’s hypertensive Ischemic Leg ulcers Are Secondary to an Increase in the Local Vascular Resistance. J Vasc Surg. 1985;2(4):581–584. doi: 10.1067/mva.1985.avs0020581.</mixed-citation><mixed-citation xml:lang="en">Duncan H.J., Faris I.B. Martorell’s hypertensive Ischemic Leg ulcers Are Secondary to an Increase in the Local Vascular Resistance. J Vasc Surg. 1985;2(4):581–584. doi: 10.1067/mva.1985.avs0020581.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Matić M., Matić A., Vučković N., Jovanović M., Golušin Z. Martorell hypertensive Ischemic Leg ulcer: A Case Report. Medicinski pregled. 2020;73(5-6):175–179. doi: 10.2298/MPNS2006175M.</mixed-citation><mixed-citation xml:lang="en">Matić M., Matić A., Vučković N., Jovanović M., Golušin Z. Martorell hypertensive Ischemic Leg ulcer: A Case Report. Medicinski pregled. 2020;73(5-6):175–179. doi: 10.2298/MPNS2006175M.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kolios A.G. A, Hafner J., Luder C., Guenova E., Kerl K., Kempf W. et al. Comparison of Pyoderma Gangrenosum and Martorell hypertensive Ischaemic Leg ulcer in a Swiss Cohort. Br J Dermatol. 2018;178(2):e125-e126. doi: 10.1111/bjd.15901.</mixed-citation><mixed-citation xml:lang="en">Kolios A.G. A, Hafner J., Luder C., Guenova E., Kerl K., Kempf W. et al. Comparison of Pyoderma Gangrenosum and Martorell hypertensive Ischaemic Leg ulcer in a Swiss Cohort. Br J Dermatol. 2018;178(2):e125-e126. doi: 10.1111/bjd.15901.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Woolling K.R. Hypertensive-Ischemic ulcer. An Atypical Ischemic Necrosis of the Skin. JAMA. 1964;187:196–201. doi: 10.1001/jama.1964.03060160024006.</mixed-citation><mixed-citation xml:lang="en">Woolling K.R. Hypertensive-Ischemic ulcer. An Atypical Ischemic Necrosis of the Skin. JAMA. 1964;187:196–201. doi: 10.1001/jama.1964.03060160024006.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Nigwekar S.U., Kroshinsky D., Nazarian R.M., Goverman J., Malhotra R., Jackson V.A. et al. Calciphylaxis: Risk Factors, Diagnosis, and Treatment. Am J Kidney Dis. 2015;6618(1):133–146. doi: 10.1053/j.ajkd.2015.01.034.</mixed-citation><mixed-citation xml:lang="en">Nigwekar S.U., Kroshinsky D., Nazarian R.M., Goverman J., Malhotra R., Jackson V.A. et al. Calciphylaxis: Risk Factors, Diagnosis, and Treatment. Am J Kidney Dis. 2015;6618(1):133–146. doi: 10.1053/j.ajkd.2015.01.034.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hafner J., Nobbe S., Läuchli S., Reutter D., Jacomella V., Amann-Vesti B. et al. ulcus hypertonicum Martorell. Schweiz Med Forum = Swiss Medical Forum. 2014;14(12):242–245. doi: 10.4414/smf.2014.01857.</mixed-citation><mixed-citation xml:lang="en">Hafner J., Nobbe S., Läuchli S., Reutter D., Jacomella V., Amann-Vesti B. et al. ulcus hypertonicum Martorell. Schweiz Med Forum = Swiss Medical Forum. 2014;14(12):242–245. doi: 10.4414/smf.2014.01857.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nigwekar S.U., Thadhani R., Brandenburg V.M. Calciphylaxis. N Engl J Med. 2018;378(18):1704–1714. doi: 10.1056/NEJMra1505292.</mixed-citation><mixed-citation xml:lang="en">Nigwekar S.U., Thadhani R., Brandenburg V.M. Calciphylaxis. N Engl J Med. 2018;378(18):1704–1714. doi: 10.1056/NEJMra1505292.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Brandenburg V.M., Kramann R., Rothe H., Kaesler N., Korbiel J., Specht P. et al. Calcific uraemic Arteriolopathy (Calciphylaxis): Data From a Large Nationwide Registry. Nephrol Dial Transplant. 2017;3218(1):126–132. doi: 10.1093/ndt/gfv438.</mixed-citation><mixed-citation xml:lang="en">Brandenburg V.M., Kramann R., Rothe H., Kaesler N., Korbiel J., Specht P. et al. Calcific uraemic Arteriolopathy (Calciphylaxis): Data From a Large Nationwide Registry. Nephrol Dial Transplant. 2017;3218(1):126–132. doi: 10.1093/ndt/gfv438.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hafner J. Calciphylaxis and Martorell hypertensive Ischemic Leg ulcer: Same Pattern – One Pathophysiology. Dermatology. 2016;232(5):523–533. doi: 10.1159/000448245.</mixed-citation><mixed-citation xml:lang="en">Hafner J. Calciphylaxis and Martorell hypertensive Ischemic Leg ulcer: Same Pattern – One Pathophysiology. Dermatology. 2016;232(5):523–533. doi: 10.1159/000448245.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kalajian A.H., Malhotra P.S., Callen J.P., Parker L.P. Calciphylaxis with Normal Renal and Parathyroid Function: Not As Rare As Previously Believed. Arch Dermatol. 2009;145(4):451–458. doi: 10.1001/archdermatol.2008.602.</mixed-citation><mixed-citation xml:lang="en">Kalajian A.H., Malhotra P.S., Callen J.P., Parker L.P. Calciphylaxis with Normal Renal and Parathyroid Function: Not As Rare As Previously Believed. Arch Dermatol. 2009;145(4):451–458. doi: 10.1001/archdermatol.2008.602.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hackett B.C., McAleer M. A., Sheehan G., Powell F.C., O’Donnell B.F. Calciphylaxis in a Patient with Normal Renal Function: Response to Treatment with Sodium Thiosulfate. Clin Exp Dermatol. 2009;3418(1):39–42. doi: 10.1111/j.1365-2230.2008.02877.x.</mixed-citation><mixed-citation xml:lang="en">Hackett B.C., McAleer M. A., Sheehan G., Powell F.C., O’Donnell B.F. Calciphylaxis in a Patient with Normal Renal Function: Response to Treatment with Sodium Thiosulfate. Clin Exp Dermatol. 2009;3418(1):39–42. doi: 10.1111/j.1365-2230.2008.02877.x.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Chafer C., Heiss A., Schwarz A., Westenfeld R., Ketteler M., Floege J. et al. The Serum Protein Alpha 2-heremans-Schmid Glycoprotein/Fetuin-A Is a Systemically Acting Inhibitor of Ectopic Calcification. J Clin Invest. 2003;112(3):357–366. doi: 10.1172/JCI17202.</mixed-citation><mixed-citation xml:lang="en">Chafer C., Heiss A., Schwarz A., Westenfeld R., Ketteler M., Floege J. et al. The Serum Protein Alpha 2-heremans-Schmid Glycoprotein/Fetuin-A Is a Systemically Acting Inhibitor of Ectopic Calcification. J Clin Invest. 2003;112(3):357–366. doi: 10.1172/JCI17202.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Galloway P.A., El-Damanawi R., Bardsley V., Pritchard N.R., Fry A.C., Ojha S.K., Hiemstra T.F. Vitamin k Antagonists Predispose to Calciphylaxis in Patients with EndStage Renal Disease. Nephron. 2015;129(3):197–201. doi: 10.1159/000371449.</mixed-citation><mixed-citation xml:lang="en">Galloway P.A., El-Damanawi R., Bardsley V., Pritchard N.R., Fry A.C., Ojha S.K., Hiemstra T.F. Vitamin k Antagonists Predispose to Calciphylaxis in Patients with EndStage Renal Disease. Nephron. 2015;129(3):197–201. doi: 10.1159/000371449.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Abutaki F.H., Alfaraj D., Alshahrani A., Elsharkawy T. Warfarin-Induced Calciphylaxis in a COVID-19 Patient. Cureus. 2020;12(12):e12249. doi: 10.7759/cureus.12249.</mixed-citation><mixed-citation xml:lang="en">Abutaki F.H., Alfaraj D., Alshahrani A., Elsharkawy T. Warfarin-Induced Calciphylaxis in a COVID-19 Patient. Cureus. 2020;12(12):e12249. doi: 10.7759/cureus.12249.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Weenig R.H., Davis M.D., Dahl P.R., Su W.P. Skin ulcers Misdiagnosed as Pyoderma Gangrenosum. N Engl J Med. 2002;347(18):1412–1418. doi: 10.1056/NEJMoa013383.</mixed-citation><mixed-citation xml:lang="en">Weenig R.H., Davis M.D., Dahl P.R., Su W.P. Skin ulcers Misdiagnosed as Pyoderma Gangrenosum. N Engl J Med. 2002;347(18):1412–1418. doi: 10.1056/NEJMoa013383.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ahronowitz I., Harp J., Shinkai K. Etiology and Management of Pyoderma Gangrenosum: A Comprehensive Review. Am J Clin Dermatol. 2012;13(3):191–211. doi: 10.2165/11595240-000000000-00000.</mixed-citation><mixed-citation xml:lang="en">Ahronowitz I., Harp J., Shinkai K. Etiology and Management of Pyoderma Gangrenosum: A Comprehensive Review. Am J Clin Dermatol. 2012;13(3):191–211. doi: 10.2165/11595240-000000000-00000.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wollina U. Pyoderma Gangrenosum – A Review. Orphanet J Rare Dis. 2007;2:19. doi: 10.1186/1750-1172-2-19.</mixed-citation><mixed-citation xml:lang="en">Wollina u. Pyoderma Gangrenosum – A Review. Orphanet J Rare Dis. 2007;2:19. doi: 10.1186/1750-1172-2-19.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Duzhiy I., Popadynets V., Nikolaienko A., Lyndіn M., Sikora V. hypertensive ulcer of Lower Extremity (Martorell’s Syndrome): Clinical Case with the Treatment Improvement. Bangladesh J Med Sci. 2017;16(2):325–328. doi: 10.3329/bjms.v16i2.31212.</mixed-citation><mixed-citation xml:lang="en">Duzhiy I., Popadynets V., Nikolaienko A., Lyndіn M., Sikora V. Hypertensive ulcer of Lower Extremity (Martorell’s Syndrome): Clinical Case with the Treatment Improvement. Bangladesh J Med Sci. 2017;16(2):325–328. doi: 10.3329/bjms.v16i2.31212.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Maverakis E., Marzano A.V., Le S.T., Callen J.P., Brüggen M.C., Guenova E. et al. Pyoderma Gangrenosum. Nat Rev Dis Primers. 2020;618(1):81. doi: 10.1038/s41572-020-0213-x.</mixed-citation><mixed-citation xml:lang="en">Maverakis E., Marzano A.V., Le S.T., Callen J.P., Brüggen M.C., Guenova E. et al. Pyoderma Gangrenosum. Nat Rev Dis Primers. 2020;618(1):81. doi: 10.1038/s41572-020-0213-x.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Konopka C.L., Padulla G.A., Ortiz M.P., Beck A.K., Bittencourt M.R., Dalcin D.C. Pioderma Gangrenoso: um Artigo de Revisão = Gangrenous Pyoderma: A Review Article. J Vasc Bras. 2013;1218(1):25–33. doi: 10.1590/S1677-54492013000100006.</mixed-citation><mixed-citation xml:lang="en">Konopka C.L., Padulla G.A., Ortiz M.P., Beck A.K., Bittencourt M.R., Dalcin D.C. Pioderma Gangrenoso: um Artigo de Revisão = Gangrenous Pyoderma: A Review Article. J Vasc Bras. 2013;1218(1):25–33. doi: 10.1590/S1677-54492013000100006.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Abbade L.P. F., Frade M.A. C., Pegas J.R. P., Dadalti-Granja P., Garcia L.C., Bueno Filho R., Parenti C.E. F. Consensus on the Diagnosis and Management of Chronic Leg ulcers – Brazilian Society of Dermatology. An Bras Dermatol. 2020;95(1 Suppl.):1–18. doi: 10.1016/j.abd.2020.06.002.</mixed-citation><mixed-citation xml:lang="en">Abbade L.P. F., Frade M.A. C., Pegas J.R. P., Dadalti-Granja P., Garcia L.C., Bueno Filho R., Parenti C.E. F. Consensus on the Diagnosis and Management of Chronic Leg ulcers – Brazilian Society of Dermatology. An Bras Dermatol. 2020;95(1 Suppl.):1–18. doi: 10.1016/j.abd.2020.06.002.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Enet P., Beneton N., Debure C., Modiano P., Lok C., Bedane C. et al. Angiodermites nécrotiques: caractéristiques épidémiologiques et facteurs pronostiques de cicatrisation dans une cohorte prospective = hypertensive Leg ulcers: Epidemiological Characteristics and Prognostic Factors for healing in a Prospective cohort. Ann Dermatol Venereol. 2012;139(5):346–349. doi: 10.1016/j.annder.2011.09.191.</mixed-citation><mixed-citation xml:lang="en">Enet P., Beneton N., Debure C., Modiano P., Lok C., Bedane C. et al. Angiodermites nécrotiques: caractéristiques épidémiologiques et facteurs pronostiques de cicatrisation dans une cohorte prospective = hypertensive Leg ulcers: Epidemiological Characteristics and Prognostic Factors for healing in a Prospective cohort. Ann Dermatol Venereol. 2012;139(5):346–349. doi: 10.1016/j.annder.2011.09.191.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Palaniswamy C., Sekhri A., Aronow W.S., Kalra A., Peterson S.J. Association of warfarin use with Valvular and Vascular Calcification: A Review. Clin Cardiol. 2011;34(2):74–81. doi: 10.1002/clc.20865.</mixed-citation><mixed-citation xml:lang="en">Palaniswamy C., Sekhri A., Aronow W.S., Kalra A., Peterson S.J. Association of warfarin use with Valvular and Vascular Calcification: A Review. Clin Cardiol. 2011;34(2):74–81. doi: 10.1002/clc.20865.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Attinger C.E., Evans K.K., Bulan E., Blume P., Cooper P. Angiosomes of the Foot and Ankle and Clinical Implications for Limb Salvage: Reconstruction, Incisions, and Revascularization. Plast Reconstr Surg. 2006;117(7 Suppl.):261S-293S. doi: 10.1097/01.prs.0000222582.84385.54.</mixed-citation><mixed-citation xml:lang="en">Attinger C.E., Evans K.K., Bulan E., Blume P., Cooper P. Angiosomes of the Foot and Ankle and Clinical Implications for Limb Salvage: Reconstruction, Incisions, and Revascularization. Plast Reconstr Surg. 2006;117(7 Suppl.):261S-293S. doi: 10.1097/01.prs.0000222582.84385.54.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sibbald R.G., Goodman L., Woo K.Y., Krasner D.L., Smart H., Tariq G. et al. Special Considerations in wound Bed Preparation 2011: An update©. Adv Skin Wound Care. 2011;24(9):415–436; quiz 437-438. doi: 110.1097/01.ASw.0000405216.27050.97.</mixed-citation><mixed-citation xml:lang="en">Sibbald R.G., Goodman L., Woo K.Y., Krasner D.L., Smart H., Tariq G. et al. Special Considerations in wound Bed Preparation 2011: An update©. Adv Skin Wound Care. 2011;24(9):415–436; quiz 437-438. doi: 110.1097/01.ASw.0000405216.27050.97.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Dagregorio G., Guillet G. A Retrospective Review of 20 hypertensive Leg ulcers Treated with Mesh Skin Grafts. J Eur Acad Dermatol Venereol. 2006;20(2):166–169. doi: 10.1111/j.1468-3083.2006.01399.x.</mixed-citation><mixed-citation xml:lang="en">Dagregorio G., Guillet G. A Retrospective Review of 20 hypertensive Leg ulcers Treated with Mesh Skin Grafts. J Eur Acad Dermatol Venereol. 2006;20(2):166–169. doi: 10.1111/j.1468-3083.2006.01399.x.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta S., Wright H.M. Nebivolol: A highly Selective Beta1-Adrenergic Receptor Blocker that Causes Vasodilation by Increasing Nitric Oxide. Cardiovasc Ther. 2008;26(3):189–202. doi: 10.1111/j.1755-5922.2008.00054.x.</mixed-citation><mixed-citation xml:lang="en">Gupta S., Wright H.M. Nebivolol: A highly Selective Beta1-Adrenergic Receptor Blocker that Causes Vasodilation by Increasing Nitric Oxide. Cardiovasc Ther. 2008;26(3):189–202. doi: 10.1111/j.1755-5922.2008.00054.x.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Pacifico F., Acernese C.A., Di Giacomo A. PGE(1) Therapy for Martorell’s ulcer. Int Wound J. 2011;8(2):140–144. doi: 10.1111/j.1742-481x.2010.00760.x.</mixed-citation><mixed-citation xml:lang="en">Pacifico F., Acernese C.A., Di Giacomo A. PGE(1) Therapy for Martorell’s ulcer. Int Wound J. 2011;8(2):140–144. doi: 10.1111/j.1742-481x.2010.00760.x.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Akakibara Y., Jikuya T., Mitsui T. Application of Lipid Microspheres Containing Prostaglandin E1 Ointment to Peripheral Ischemic ulcers. Dermatology. 1997;195(3):253–257. doi: 10.1159/000245954.</mixed-citation><mixed-citation xml:lang="en">Akakibara Y., Jikuya T., Mitsui T. Application of Lipid Microspheres Containing Prostaglandin E1 Ointment to Peripheral Ischemic ulcers. Dermatology. 1997;195(3):253–257. doi: 10.1159/000245954.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Leloup P., Toussaint P., Lembelembe J.P., Célérier P., Maillard H. The Analgesic Effect of Electrostimulation (woundEL®) in the Treatment of Leg ulcers. Int Wound J. 2015;12(6):706–709. doi: 10.1111/iwj.12211.</mixed-citation><mixed-citation xml:lang="en">Leloup P., Toussaint P., Lembelembe J.P., Célérier P., Maillard H. The Analgesic Effect of Electrostimulation (woundEL®) in the Treatment of Leg ulcers. Int Wound J. 2015;12(6):706–709. doi: 10.1111/iwj.12211.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Castana O., Dimitrouli A., Argyrakos T., Theodorakopoulou E., Stampolidis N., Papadopoulos E. et al. wireless Electrical Stimulation: An Innovative Powerful Tool for the Treatment of a Complicated Chronic ulcer. Int J Low Extrem Wounds. 2013;1218(1):18–21. doi: 10.1177/1534734613476517.</mixed-citation><mixed-citation xml:lang="en">Castana O., Dimitrouli A., Argyrakos T., Theodorakopoulou E., Stampolidis N., Papadopoulos E. et al. wireless Electrical Stimulation: An Innovative Powerful Tool for the Treatment of a Complicated Chronic ulcer. Int J Low Extrem Wounds. 2013;1218(1):18–21. doi: 10.1177/1534734613476517.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Cameron T. Safety and Efficacy of Spinal Cord Stimulation for the Treatment of Chronic Pain: A 20-Year Literature Review. J Neurosurg. 2004;100(3 Suppl. Spine):254–267. doi: 10.3171/spi.2004.100.3.0254.</mixed-citation><mixed-citation xml:lang="en">Cameron T. Safety and Efficacy of Spinal Cord Stimulation for the Treatment of Chronic Pain: A 20-Year Literature Review. J Neurosurg. 2004;100(3 Suppl. Spine):254–267. doi: 10.3171/spi.2004.100.3.0254.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">De Andrés J., Villanueva V.L., Mazzinari G., Fabregat G., Asensio J.M., Monsalve V. use of a Spinal Cord Stimulator for Treatment of Martorell hypertensive ulcer. Reg Anesth Pain Med. 2011;3618(1):83–86. doi: 10.1097/AAP.0b013e31820308b2.</mixed-citation><mixed-citation xml:lang="en">De Andrés J., Villanueva V.L., Mazzinari G., Fabregat G., Asensio J.M., Monsalve V. use of a Spinal Cord Stimulator for Treatment of Martorell hypertensive ulcer. Reg Anesth Pain Med. 2011;3618(1):83–86. doi: 10.1097/AAP.0b013e31820308b2.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Ramadhinara A., Poulas K. Use of wireless Microcurrent Stimulation for the Treatment of Diabetes-Related wounds: 2 Case Reports. Adv Skin Wound Care. 2013;2618(1):1–4. doi: 10.1097/01.ASw.0000425942.32993.e9.</mixed-citation><mixed-citation xml:lang="en">Ramadhinara A., Poulas K. use of wireless Microcurrent Stimulation for the Treatment of Diabetes-Related wounds: 2 Case Reports. Adv Skin Wound Care. 2013;2618(1):1–4. doi: 10.1097/01.ASw.0000425942.32993.e9.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Wirsing P.G., Habrom A.D., Zehnder T.M., Friedli S., Blatti M. Wireless Micro Current Stimulation – An Innovative Electrical Stimulation Method for the Treatment of Patients with Leg and Diabetic Foot ulcers. Int Wound J. 2015;12(6):693–698. doi: 10.1111/iwj.12204.</mixed-citation><mixed-citation xml:lang="en">Wirsing P.G., Habrom A.D., Zehnder T.M., Friedli S., Blatti M. Wireless Micro Current Stimulation – An Innovative Electrical Stimulation Method for the Treatment of Patients with Leg and Diabetic Foot ulcers. Int Wound J. 2015;12(6):693–698. doi: 10.1111/iwj.12204.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Wirsing P.G., Konstantakaki M., Poulas K.A. Martorell’s ulcer Successfully Treated by wireless Microcurrent Stimulation Technology. Adv Skin Wound Care. 2019;32(2):81–84. doi: 10.1097/01.ASw.0000550590.31545.67.</mixed-citation><mixed-citation xml:lang="en">Wirsing P.G., Konstantakaki M., Poulas K.A. Martorell’s ulcer Successfully Treated by wireless Microcurrent Stimulation Technology. Adv Skin Wound Care. 2019;32(2):81–84. doi: 10.1097/01.ASw.0000550590.31545.67.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Vuerstaek J.D., Vainas T., Wuite J., Nelemans P., Neumann M.H., Veraart J.C. State-of-the-Art Treatment of Chronic Leg ulcers: A Randomized Controlled Trial Comparing Vacuum-Assisted Closure (V.A. C.) with Modern wound Dressings. J Vasc Surg. 2006;44(5):1029–1037; discussion 1038. doi: 10.1016/j.jvs.2006.07.030.</mixed-citation><mixed-citation xml:lang="en">Vuerstaek J.D., Vainas T., Wuite J., Nelemans P., Neumann M.H., Veraart J.C. State-of-the-Art Treatment of Chronic Leg ulcers: A Randomized Controlled Trial Comparing Vacuum-Assisted Closure (V.A. C.) with Modern wound Dressings. J Vasc Surg. 2006;44(5):1029–1037; discussion 1038. doi: 10.1016/j.jvs.2006.07.030.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Akhlak H., Kuldip S., Mohinder S. Cost Effectiveness of VacuumAssisted Closure and Its Modifications: A Review. Int Schol Res Notices. 2013:595789. doi: 10.5402/2013/595789.</mixed-citation><mixed-citation xml:lang="en">Akhlak H., Kuldip S., Mohinder S. Cost Effectiveness of VacuumAssisted Closure and Its Modifications: A Review. Int Schol Res Notices. 2013:595789. doi: 10.5402/2013/595789.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin C., Dissemond J. Therapierefraktäres ulcus cruris. Ulcus cruris hypertonicum (Martorell) = Therapy-Refractory Leg ulcer. Martorell hypertensive Ischemic Leg ulcer. J Dtsch Dermatol Ges. 2011;9(11):951–952. doi: 10.1111/j.1610-0387.2011.07789.x.</mixed-citation><mixed-citation xml:lang="en">Franklin C., Dissemond J. Therapierefraktäres ulcus cruris. ulcus cruris hypertonicum (Martorell) = Therapy-Refractory Leg ulcer. Martorell hypertensive ischemic leg ulcer. J Dtsch Dermatol Ges. 2011;9(11):951–952. doi: 10.1111/j.1610-0387.2011.07789.x.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Erpa M.J., Franco S., Repolho D., Araújo I., Mateus S., Baptista A.M., Araújo J.L. A Challenging Diagnosis of Leg ulcer. Eur J Case Rep Intern Med. 2018;5(10):000952. doi: 10.12890/2018_000952.</mixed-citation><mixed-citation xml:lang="en">Erpa M.J., Franco S., Repolho D., Araújo I., Mateus S., Baptista A.M., Araújo J.L. A Challenging Diagnosis of Leg ulcer. Eur J Case Rep Intern Med. 2018;5(10):000952. doi: 10.12890/2018_000952.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Palou J. Lumber Sympathectomy in the Treatment of hypertensive Ischemic ulcers of the Leg (Martorell’s Syndrome). Circulation. 1955;12(2):239–241. doi: 10.1161/01.cir.12.2.239.</mixed-citation><mixed-citation xml:lang="en">Palou J. Lumber Sympathectomy in the Treatment of hypertensive Ischemic ulcers of the Leg (Martorell’s Syndrome). Circulation. 1955;12(2):239–241. doi: 10.1161/01.cir.12.2.239.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Fıçıcıoğlu S., Can N., Tutuğ B. A Case of Chronic ulcer Due to Subcutaneous Arteriolosclerosis in an Obese Patient Mimicking Pyoderma Gangrenosum. Dermatol Reports. 2018;1018(1):7445. doi: 10.4081/dr.2018.7445.</mixed-citation><mixed-citation xml:lang="en">Fıçıcıoğlu S., Can N., Tutuğ B. A Case of Chronic ulcer Due to Subcutaneous Arteriolosclerosis in an Obese Patient Mimicking Pyoderma Gangrenosum. Dermatol Reports. 2018;1018(1):7445. doi: 10.4081/dr.2018.7445.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Dissemond J., Erfurt-Berge C., Goerge T., Kröger K., FunkeLorenz C., Reich-Schupke S. Systemic Therapies for Leg ulcers. J Dtsch Dermatol Ges. 2018;16(7):873–890. doi: 10.1111/ddg.13586.</mixed-citation><mixed-citation xml:lang="en">Dissemond J., Erfurt-Berge C., Goerge T., Kröger K., FunkeLorenz C., Reich-Schupke S. Systemic Therapies for Leg ulcers. J Dtsch Dermatol Ges. 2018;16(7):873–890. doi: 10.1111/ddg.13586.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Rongisch R., Haese S., Eming S.A. 38/w mit therapieresistentem ulcus cruris: Vorbereitung auf die Facharztprüfung: Folge 48 = 38-Year-Old Female with a TREATMENT-resistant ulcer: Preparation for the Specialist Examination: Part 48. Hautarzt. 2019;70(1 Suppl.):81–84. doi: 10.1007/s00105-019-4364-1.</mixed-citation><mixed-citation xml:lang="en">Rongisch R., Haese S., Eming S.A. 38/w mit therapieresistentem ulcus cruris: Vorbereitung auf die Facharztprüfung: Folge 48 = 38-Year-Old Female with a TREATMENT-resistant ulcer: Preparation for the Specialist Examination: Part 48. Hautarzt. 2019;70(1 Suppl.):81–84. doi: 10.1007/s00105-019-4364-1.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Dissemond J. Chronisches ulcus cruris = Chronic Leg ulcers. Hautarzt. 2017;68(8):614–620. doi: 10.1007/s00105-017-4010-8.</mixed-citation><mixed-citation xml:lang="en">Dissemond J. Chronisches ulcus cruris = Chronic Leg ulcers. Hautarzt. 2017;68(8):614–620. doi: 10.1007/s00105-017-4010-8.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Eisendle K., Thuile T., Deluca J., Pichler M. Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure wound Therapy and Skin Grafting, Including xenografts: Personal Experience and Comprehensive Review on 161 Cases. Adv Wound Care (New Rochelle). 2020;9(7):405–425. doi: 10.1089/wound.2020.1160.</mixed-citation><mixed-citation xml:lang="en">Eisendle K., Thuile T., Deluca J., Pichler M. Surgical Treatment of Pyoderma Gangrenosum with Negative Pressure wound Therapy and Skin Grafting, Including xenografts: Personal Experience and Comprehensive Review on 161 Cases. Adv Wound Care (New Rochelle). 2020;9(7):405–425. doi: 10.1089/wound.2020.1160.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
