asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/1995-1477-2019-3-4-19-33asurgery-156Research ArticleАМБУЛАТОРНАЯ ФЛЕБОЛОГИЯAMBULATORY PHLEBOLOGYСТАТЬЯ ОТОЗВАНА: Патогенетическое обоснование флеботропной терапии хронических заболеваний венRETRACTED: Pathogenetic substantiation of phlebotropic therapy for chronic venous diseaseshttps://orcid.org/0000-0002-3940-0787БогачевВ. Ю.BogachevV. Yu.

д.м.н., профессор, кафедра факультетской хирургии № 2

117997, Россия, Москва, ул. Островитянова, д. 1

117447, Россия, Москва, ул. Дмитрия Ульянова, д. 31

Dr. of Sci. (Med.), Professor, Chair for Intermediate Level Surgery No. 2,

1 Ostrovityanova St., Moscow, 117997, Russia;

31 Dmitriya Ul’yanova St., Moscow, 117447, Russia

vadim.bogachev63@gmail.comhttps://orcid.org/0000-0002-6722-0476МансильяА.MansillaA.

доктор, профессор, директор отдела ангиологии и сосудистой хирургии медицинского факультета

Португалия, Порто, ул. Хулио Диниса, 826, 5

Dr. of Sci. (Med.), Professor, Director of Department of Angiology and Vascular Surgery, Faculty of Medicine,

5, 826 Julio Diniz St., Porto, Portugal

vascular.mansilha@gmail.comhttps://orcid.org/0000-0003-4488-9123БолдинБ. В.BoldinB. V.

д.м.н., профессор, заведующий кафедрой факультетской хирургии № 2

 117997, Россия, Москва, ул. Островитянова, д. 1

Dr. of Sci. (Med.), Professor, Head of Chair for Intermediate Level Surgery No. 2

1 Ostrovityanova St., Moscow, 117997, Russia

facultysurgery@gmail.comРодионовС. В.RodionovS. V.

д.м.н., профессор, кафедра факультетской хирургии № 2

 117997, Россия, Москва, ул. Островитянова, д. 1

Dr. of Sci. (Med.), Professor, Chair for Intermediate Level Surgery No. 2

1 Ostrovityanova St., Moscow, 117997, Russia

facultysurgery@gmail.comДженинаО. В.DzheninaO. V.

к.м.н., врач-флеболог

117447, Россия, Москва, ул. Дмитрия Ульянова, д. 31

Cand. of Sci. (Med.), Phlebologist

31 Dmitriya Ul’yanova St., Moscow, 117447, Russia

dzhenina@rambler.ruРоссийский национальный исследовательский медицинский университет имени Н. И. Пирогова, Первый флебологический центрРоссияFederal State Budgetary Educational Institution of Higher Education “Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation, First Phlebological Center Limited Liability CompanyRussian FederationУниверситет ПортоПортугалияUniversity of PortoPortugalРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияFederal State Budgetary Educational Institution of Higher Education “Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian FederationRussian FederationРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияFederal State Budgetary Educational Institution of Higher Education “Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian FederationRussian FederationПервый флебологический центрРоссияFirst Phlebological Center Limited Liability CompanyRussian Federation20191411201903-41933Copyright © Богачев В.Ю., Мансилья А., Болдин Б.В., Родионов С.В., Дженина О.В., 20192019Богачев В.Ю., Мансилья А., Болдин Б.В., Родионов С.В., Дженина О.В.Bogachev V.Y., Mansilla A., Boldin B.V., Rodionov S.V., Dzhenina O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/156

СТАТЬЯ ОТОЗВАНА

Хронические заболевания вен (ХЗВ) являются самой распространенной сосудистой патологией, оказывающей значительное негативное физическое и психологическое воздействие на пациентов, а также требующей больших экономических затрат со стороны национальных систем здравоохранения. В последние десятилетия был выявлен ряд факторов риска ХЗВ, но лишь недавно стала обсуждаться роль воспаления и дисфункции эндотелия. Современные знания позволяют выделить несколько приоритетных стратегий и целей, направленных на коррекцию основных патофизиологических механизмов развития и прогрессирования ХЗВ. В частности, применение веноактивных препаратов, роль которых в повышении тонуса и сократимости вен, уменьшении воспаления и отека, а также улучшении микроциркуляции и ускорении заживления венозных язв была тщательно изучена и с положительными результатами представлена в различных публикациях. В данном обзоре представлены различные патофизиологические механизмы развития ХЗВ, которые и служат целями для лекарственной терапии с помощью ряда веноактивных препаратов.

RETRACTED ARTICLE

Chronic venous disease (CVD) is the most common vascular pathology that has a significant negative effect on physical and psychological health outcomes, and requires high level of public spending on healthcare. Number of CVD risk factors has been identified in recent decades, but only recently have the experts begun to discuss the role of inflammation and endothelial dysfunction. Modern knowledge enables us to identify several priority strategies and goals aimed at managing the basic pathophysiological mechanisms of the development and progression of CVD. In particular, the use of venoactive drugs, which role in enhancing vascular tone and contractility, reducing inflammation and edema and improving microcirculation and accelerating the healing of venous leg ulcers has been carefully studied and presented with positive outcomes in various publications. This review provides various pathophysiological mechanisms of the development of CVD, which present the targets for venoactive drug therapies.

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The authors declare that there are no conflicts of interest present.