asurgeryАмбулаторная хирургияAmbulatornaya khirurgiya = Ambulatory Surgery (Russia)2712-87412782-2591ООО «ГРУППА РЕМЕДИУМ»10.21518/1995-1477-2018-3-4-66-71asurgery-124Research ArticleГНОЙНЫЕ И ТРОФИЧЕСКИЕ ПОРАЖЕНИЯPURULENT AND TROPHIC LESIONSМесто и роль топических антисептиков в терапии ожоговкожи: позиция дерматологаPlace and role of topical antiseptic agents in the treatment of skin burns from the standpoint of adermatologistЖучковМ. В.ZhuchkovM. V.

Жучков Михаил Валерьевич– кандидат медицинских наук, главный внештатный дерматовенеролог и косметолог Министерства здравоохраненияРязанской области, заместитель главного врача ГБУ РО «Областной клинический кожно-венерологический диспансер»

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БольшаковаЕ. Е.BolshakovaE. E.

Большакова Елена Евгеньевна– главный врач ГБУ РО «Областной клинический кожно-венерологический диспансер»,председатель Рязанского регионального отделения Российского общества дерматовенерологов и косметологов

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СонинД. Б.SoninD. B.

Сонин Дмитрий Борисович– кандидат медицинских наук, заместитель главного врача

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ЖучковаУ. В.ZhuchkovaU. V.

Жучкова Ульяна Владимировна– врач-хирург

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ГБУ РО «Областной клинический кожно-венерологический диспансер»РоссияRegional Clinical Dermatovenerologic DispensaryRussian FederationГБУ РО «Городская клиническая больница скорой медицинской помощи»РоссияCity Clinical Emergency Care HospitalRussian Federation20180412201803-46671Copyright © Жучков М.В., Большакова Е.Е., Сонин Д.Б., Жучкова У.В., 20182018Жучков М.В., Большакова Е.Е., Сонин Д.Б., Жучкова У.В.Zhuchkov M.V., Bolshakova E.E., Sonin D.B., Zhuchkova U.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.a-surgeon.ru/jour/article/view/124

В статье приводятся данные литературы и собственные наблюдения авторов, посвященные современному состоянию вопроса о клиническом применении октенидина дигидрохлорида ифеноксиэтанола в клинической и амбулаторной хирургии при термических ожогах кожи.

The article presents the literature data and the authors’ own observations on the current state of the issue in the clinical use of octenidine dihydrochloride and phenoxyethanol in thermal burns of the skin in clinical and outpatient surgery.

октенидина дигидрохлоридфеноксиэтанолМестаМидин-сенсамбулаторная хирургияoctenidine dihydrochloridephenoxyethanolMestaMidin-Sensoutpatient surgeryReferencesMartin S.F., Rustemeyer T., Thyssen J.P. Recent advances in understanding and managing contact dermatitis. F1000Res, 2018 Jun 20, 7.Martin S.F., Rustemeyer T., Thyssen J.P. Recent advances in understanding and managing contact dermatitis. F1000Res, 2018 Jun 20, 7.Kuniyuki S., Oonishi H. Chemical burn from acetic acid with deep ulceration. Contact Dermatitis, 1997 Mar, 36(3): 169-170.Kuniyuki S., Oonishi H. Chemical burn from acetic acid with deep ulceration. Contact Dermatitis, 1997 Mar, 36(3): 169-170.Walker J.Jr. The pathologic physiology of the extensive superficial burn. Surg Clin North Am,1946 Dec, 26: 1488-1497.Walker J.Jr. The pathologic physiology of the extensive superficial burn. Surg Clin North Am,1946 Dec, 26: 1488-1497.Байков Д.А., Мавлютов Т.Р., Гаймалетдинов А.З. Современные технологии в лечении амбулаторных ожогов, Актуальные проблемы термической травмы: Материалы международной конференции, Санкт-Петербург, 2002: 240-241.Baikov DA, Mavlyutov TR, Gaymaletdinov AZ. New technologies in the ambulatory management of burns, Topical issues of thermal injury: Proceedings of the international conference, St. Petersburg, 2002: 240-241.Hall C., Hardin C., Corkins C.J., Jiwani A.Z., Fletcher J., Carlsson A., Chan R. Pathophysiologic Mechanisms and Current Treatments for Cutaneous Sequelae of Burn Wounds. Compr Physiol, 2017 Dec 12, 8(1): 371-405.Hall C., Hardin C., Corkins C.J., Jiwani A.Z., Fletcher J., Carlsson A., Chan R. Pathophysiologic Mechanisms and Current Treatments for Cutaneous Sequelae of Burn Wounds. Compr Physiol, 2017 Dec 12, 8(1): 371-405.Slee A.M., O’Connor J.R. In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms. Antimicrob Agents Chemother, 1983 Mar, 23(3): 379-384.Slee A.M., O’Connor J.R. In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms. Antimicrob Agents Chemother, 1983 Mar, 23(3): 379-384.Harke H.P. Octenidine dihydrochloride, properties of a new antimicrobial agent. Zentralbl Hyg Umweltmed, 1989 May, 188(1-2): 188-93.Harke H.P. Octenidine dihydrochloride, properties of a new antimicrobial agent. Zentralbl Hyg Umweltmed, 1989 May, 188(1-2): 188-93.Beiswanger B.B., Mallatt M.E., Mau M.S., Jackson R.D., Hennon D.K. The clinical effects of a mouthrinse containing 0.1% octenidine. J Dent Res, 1990 Feb, 69(2): 454-457.Beiswanger B.B., Mallatt M.E., Mau M.S., Jackson R.D., Hennon D.K. The clinical effects of a mouthrinse containing 0.1% octenidine. J Dent Res, 1990 Feb, 69(2): 454-457.Sloot N., Siebert J., Höffler U. Eradication of MRSA from carriers by means of whole-body washing with an antiseptic in combination with mupirocin nasal ointment. Zentralbl Hyg Umweltmed, 1999 Dec, 202(6): 513-523.Sloot N., Siebert J., Höffler U. Eradication of MRSA from carriers by means of whole-body washing with an antiseptic in combination with mupirocin nasal ointment. Zentralbl Hyg Umweltmed, 1999 Dec, 202(6): 513-523.Alvarez-Marin R., Aires-de-Sousa M., Nordmann P., Kieffer N., Poirel L. Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens. Eur J Clin Microbiol Infect Dis, 2017 Dec, 36(12): 2379-2383.Alvarez-Marin R., Aires-de-Sousa M., Nordmann P., Kieffer N., Poirel L. Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens. Eur J Clin Microbiol Infect Dis, 2017 Dec, 36(12): 2379-2383.Koburger T., Hübner N.O., Braun M., Siebert J., Kramer A. Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J Antimicrob Chemother, 2010 Aug, 65(8): 1712-1719.Koburger T., Hübner N.O., Braun M., Siebert J., Kramer A. Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J Antimicrob Chemother, 2010 Aug, 65(8): 1712-1719.Kramer A., Dissemond J., Kim S., Willy C., Mayer D., Papke R., Tuchmann F., Assadian O. Consensus on Wound Antisepsis: Update 2018. Skin Pharmacol Physiol, 2018, 31(1): 28-58.Kramer A., Dissemond J., Kim S., Willy C., Mayer D., Papke R., Tuchmann F., Assadian O. Consensus on Wound Antisepsis: Update 2018. Skin Pharmacol Physiol, 2018, 31(1): 28-58.Sopata M., Kucharzewski M., Tomaszewska E. Antiseptic with modern wound dressings in the treatment of venous leg ulcers: clinical and microbiological aspects. J Wound Care, 2016 Aug, 25(8): 419-426.Sopata M., Kucharzewski M., Tomaszewska E. Antiseptic with modern wound dressings in the treatment of venous leg ulcers: clinical and microbiological aspects. J Wound Care, 2016 Aug, 25(8): 419-426.Dettenkofer M., Wilson C., Gratwohl A., Schmoor C., Bertz H., Frei R., Heim D., Luft D., Schulz S., Widmer A.F. Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect, 2010 Jun, 16(6): 600-606.Dettenkofer M., Wilson C., Gratwohl A., Schmoor C., Bertz H., Frei R., Heim D., Luft D., Schulz S., Widmer A.F. Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial. Clin Microbiol Infect, 2010 Jun, 16(6): 600-606.Zumtobel M., Assadian O., Leonhard M., Stadler M., Schneider B. The antimicrobial effect of Octenidine-dihydrochloride coated polymer tracheotomy tubes on Staphylococcus aureus and Pseudomonas aeruginosa colonization. BMC Microbiol, 2009 Jul. 25, 9: 150.Zumtobel M., Assadian O., Leonhard M., Stadler M., Schneider B. The antimicrobial effect of Octenidine-dihydrochloride coated polymer tracheotomy tubes on Staphylococcus aureus and Pseudomonas aeruginosa colonization. BMC Microbiol, 2009 Jul. 25, 9: 150.Eisenbei W., Siemers F., Amtsberg G., Hinz P., Hartmann B., Kohlmann T., Ekkernkamp A., Albrecht U., Assadian O., Kramer A. Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma, 2012, 2(2): 71–79.Eisenbei W., Siemers F., Amtsberg G., Hinz P., Hartmann B., Kohlmann T., Ekkernkamp A., Albrecht U., Assadian O., Kramer A. Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma, 2012, 2(2): 71–79.Vanbreuseghem R. Fungicidal and fungistatic effect of p-chlorophenoxethol and propylene phenoxethol on African dermatophytes. Ann Soc Belg Med Trop, 1950 Sep, 30(3): 601-607.Vanbreuseghem R. Fungicidal and fungistatic effect of p-chlorophenoxethol and propylene phenoxethol on African dermatophytes. Ann Soc Belg Med Trop, 1950 Sep, 30(3): 601-607.Hugo W.B. The action of phenol and 2-phenoxyethanol on the oxidation of various substances by Escherichia coli and by a disrupted cell preparation of the organism. J Gen Microbiol, 1956 Oct, 15(2): 315-323.Hugo W.B. The action of phenol and 2-phenoxyethanol on the oxidation of various substances by Escherichia coli and by a disrupted cell preparation of the organism. J Gen Microbiol, 1956 Oct, 15(2): 315-323.Gilbert P., Beveridge E.G., Crone P.B. Inhibition of some respiration and dehydrogenase enzyme systems in Escherichia coli NCTC 5933 by phenoxyethanol. Microbios, 1977, 20(79): 29-37.Gilbert P., Beveridge E.G., Crone P.B. Inhibition of some respiration and dehydrogenase enzyme systems in Escherichia coli NCTC 5933 by phenoxyethanol. Microbios, 1977, 20(79): 29-37.Mayr-Kanhäuser S., Kränke B., Aberer W. Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne. Acta Dermatovenerol Alp Pannonica Adriat, 2008 Sep, 17(3): 139-143.Mayr-Kanhäuser S., Kränke B., Aberer W. Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne. Acta Dermatovenerol Alp Pannonica Adriat, 2008 Sep, 17(3): 139-143.Núñez Orjales R., Carballas Vázquez C., Carballada González F., Boquete París M. 2-phenoxyethanol-induced contact urticaria and anaphylaxis. J Investig Allergol Clin Immunol, 2010, 20(4): 354-355.Núñez Orjales R., Carballas Vázquez C., Carballada González F., Boquete París M. 2-phenoxyethanol-induced contact urticaria and anaphylaxis. J Investig Allergol Clin Immunol, 2010, 20(4): 354-355.Lilienblum W. Opinion of the Scientific Committee on Consumer Safety (SCCS) – Final version of the opinion on Phenoxyethanol in cosmetic products. Regul Toxicol Pharmacol, 2016 Dec, 82: 156.Lilienblum W. Opinion of the Scientific Committee on Consumer Safety (SCCS) – Final version of the opinion on Phenoxyethanol in cosmetic products. Regul Toxicol Pharmacol, 2016 Dec, 82: 156.Bührer C., Bahr S., Siebert J., Wettstein R., Geffers C., Obladen M. Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation. J Hosp Infect, 2002 Aug, 51(4): 305-307.Bührer C., Bahr S., Siebert J., Wettstein R., Geffers C., Obladen M. Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation. J Hosp Infect, 2002 Aug, 51(4): 305-307.Novakov Mikić A., Stojic S. Study results on the use of different therapies for the treatment of vaginitis in hospitalised pregnant women. Arch Gynecol Obstet, 2015 Aug, 292(2): 371376.Novakov Mikić A., Stojic S. Study results on the use of different therapies for the treatment of vaginitis in hospitalised pregnant women. Arch Gynecol Obstet, 2015 Aug, 292(2): 371376.Hajská M., Slobodníková L., Hupková H., Koller J. In vitro efficacy of various topical antimicrobial agents in different time periods from contamination to application against 6 multidrug-resistant bacterial strains isolated from burn patients. Burns, 2014 Jun, 40(4): 713-718.Hajská M., Slobodníková L., Hupková H., Koller J. In vitro efficacy of various topical antimicrobial agents in different time periods from contamination to application against 6 multidrug-resistant bacterial strains isolated from burn patients. Burns, 2014 Jun, 40(4): 713-718.

The authors declare that there are no conflicts of interest present.