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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">asurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Амбулаторная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8741</issn><issn pub-type="epub">2782-2591</issn><publisher><publisher-name>ООО «ГРУППА РЕМЕДИУМ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/1995-1477-2018-3-4-36-41</article-id><article-id custom-type="elpub" pub-id-type="custom">asurgery-120</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФЛЕБОЛОГИЯ | АНГИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHLEBOLOGY | ANGIOLOGY</subject></subj-group></article-categories><title-group><article-title>Лечение хронической венозной недостаточности нижних конечностей</article-title><trans-title-group xml:lang="en"><trans-title>Management of chronic venous insufficiency of the lower extremities</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудыкин</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudykin</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кудыкин Максим Николаевич – доктор медицинских наук, профессор, вице-президент Ассоциации флебологов России, исполнительный директор Ассоциации ангиологов, флебологов и сосудистых хирургов Нижегородской области (ААФСХ)</p><p>Нижний Новгород</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ассоциация флебологов России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Association of Phlebologists</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2018</year></pub-date><volume>0</volume><issue>3-4</issue><fpage>36</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кудыкин М.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кудыкин М.Н.</copyright-holder><copyright-holder xml:lang="en">Kudykin M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.a-surgeon.ru/jour/article/view/120">https://www.a-surgeon.ru/jour/article/view/120</self-uri><abstract><p>Представлены современные сведения об эпидемиологии, патогенезе и клинических проявлениях хронических заболеваний вен и хронической венозной недостаточности нижних конечностей. Обсуждается механизм действия различных флеботропных препаратов, предназначенных для терапии симптомов хронических заболеваний вен и хронической венозной недостаточности, приводятся данные о преимуществах микронизированной очищенной флавоноидной фракции для терапии всех клинических классов хронических заболеваний вен.</p></abstract><trans-abstract xml:lang="en"><p>The article presents up-to-date information about epidemiology, pathogenesis and clinical manifestations of chronic venous diseases and chronic venous insufficiency of the lower extremities. It discusses the mechanism of action of various phlebotrophic drugs intended for the treatment of symptoms of chronic venous diseases and chronic venous insufficiency and describes the advantages of micronized purified flavonoid fraction for the treatment of all clinical classes of chronic venous diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронические заболевания вен</kwd><kwd>хроническая венозная недостаточность</kwd><kwd>варикозная болезнь</kwd><kwd>посттромботический синдром</kwd><kwd>диосмин</kwd><kwd>микронизированная очищенная флавоноидная фракция</kwd><kwd>флеботропная терапия</kwd><kwd>детравенол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic venous diseases</kwd><kwd>chronic venous insufficiency</kwd><kwd>varicose veins</kwd><kwd>post-thrombotic syndrome</kwd><kwd>diosmin</kwd><kwd>micronized purified flavonoid fraction</kwd><kwd>phlebotrophic therapy</kwd><kwd>detravenol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шлякова А.А., Корнева К.Г., Кудыкин М.Н., Перетягин П.В. 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